[Abstract] Objective：To investigate the changes of the serum level of highly sensitive C-reactive protein(hs-CRP) in Type 2 diabetic nephropathy (DN) patients complicated by acue cerebral infarction and to explore the relationship of reaction of microinflammation in DN and ischemic stroke. Methods：Totally 96 acute cerebral infarction patients who were hospitalized in our hospital from January 2006 to June 2009 were included in this study. Urinary albumin excretion rate (UAER), hs-CRP, scores of the Nation Institute of Health Stroke Scale (NIHSS) and other related factors were investigated. According to the results of UAER, cases of type 2 diabetes mellitus (T2DM) were divided into normal albumin urinary group (NA), micro albumin urinary group (MA), and clinical albumin group (CP). Results：In the 96 cases, T2DM accounted for 58.33% (56/96). The serum level of hs-CRP in the patients with T2DM was significantly higher than that in non-T2DM (P <0.01). There was not significant difference in serum hs-CRP level between group NA, MA, CP and non-T2DM group. Between group NA, MA and non-T2DM, the difference was noted (P <0.01). Meanwhile,there was also significant difference in serum hs-CPR of CP compared with that of MA (P <0.01). Scores of NIHSS was significantly higher in T2DM group than in non-T2DM patients（P <0.01）. Furthermore, the rate of death in T2DM patients more increased than in non-T2DM group（P <0.01）. Moreover, the rate of death in hs-CRP positive group significantly increased compare to hs-CRP negative group（P <0.01）. Conclusion： Acute cerebral infarction with DN exist reaction of microinflammation normally, it may be influence the state acute cerebral infarction and it's prognosis. The hs-CRP level of patients with DN complicated acute cerebral infarction might predict patient's condition and prognosis. [Keywords] type 2 diabetic nephropathy; acute cerebral infarction; reaction of microinflammation; highly sensitive C-reactive protein