[Abstract] Objective To observe the local control rate and serious toxicity on the 3-dimensional conformal radiation therapy in elderly patients with Ⅲ non-small cell lung cancer. Method : 65cases with NSCLC elderly patients were randomly divided into two groups: A group and B group. A group included 32cases treated with senate ligusticum glucose injection on the 3-dimensional conformal radiation therapy, B group included 33 cases with vitＣ and vitＢ6 injection. To observe the clinical characteristic of tumor, recent effects, toxication and side effects and survival condition（postoperative survival rate in 3,6,12 and 18month, respectively）. Results The CR rate of group A is higher than that of group B(p<0.05). Postoperative survival rate of A group were 96.88 % 、90.63％、71.9％ and 34.4％in 3,6,12,and18month；B group were 93.94 % 、72.73％、60.6％ and 27.3％in 3,6,12,and18month respectively, no significant difference from that of B group. The side effects and toxications of A groups was better than B group. Conclusion Senate ligusticum glucose injection on the 3-dimensioconformal radiation therapy in elderly patients with Ⅲ non-small cell lung cancer could reduced the side effects and toxications of tumor, significant difference between the two groups .