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肾母细胞瘤中cyclinD1和P16蛋白的表达研究
作者:周峥珍  
单位:湖南省儿童医院
关键词:肾母细胞瘤 cyclinD1  P16  免疫组化 
分类号:
出版年·卷·期(页码):2010·38·第六期(609-612)
摘要:

目的 探讨cyclinD1和P16蛋白在肾母细胞瘤发生发展中的作用及其与临床病理特征的关系。方法 应用免疫组化法测定36例肾母细胞瘤和8例正常肾脏组织中cyclinD1和P16蛋白的表达。结果 (1)肾母细胞瘤中cyclinD1蛋白及P16蛋白的表达阳性率分别为55.56%(20/36),61.11%(22/36);肾母细胞瘤组cyclinD1蛋白与正常组比较差异有显著性(P < 0.05),瘤组织P16蛋白与正常组比较差异无显著性(P>0.05);(2) 肾母细胞瘤的组织分型、临床分期和有无淋巴结转移对cyclinD1和P16蛋白表达的影响无显著性差异(P > 0.05),(3)cyclinD1蛋白与P16蛋白的表达无明显相关性(P > 0.05)。 结论 (1)cyclinD1蛋白的高表达与肾母细胞瘤的发生密切相关。(2)cyclinD1和P16蛋白的浆型表达与该肿瘤的发生密切相关。

Objective To explore the roles of CyclinD1 and P16 proteins in the oncogenesis of nephroblastoma and the relationship between these two protein production and the pathological characteristics of nephroblastoma. Methods Immunohistochemical technique was applied to detect the expression of CyclinD1 and P16 in 36 cases of nephroblastoma and 8 cases of normal nephritic tissues. Results (1) The expression of cyclinD1 and P16 in the nephroblastoma tissues is 55.56%(20/36),and 61.11%(22/36), respectively; There was a significant difference in the CyclinDl between the nephroblastoma tissue and normal tissue(P < 0.05), no significant difference in the P16 between the nephroblastoma tissue and normal tissue(P>0.05) (2) There were no significant difference in the CyclinD1 and P16 protein about the histological typing ,clinical stage, lymph node metastases , respectively (P > 0.05); (3) There was no correlation between the expression of CyclinD1 and P16 (r(s) =-0.025, P > 0.05). Conclusions (1)The over-expression of cyclinD1 is highly related to the oncogenesis of nephroblastoma.(2)Cytoplasmic staining patterns of cyclinD1 and P16 positive cell may be associate with the occurrence of nephroblastoma.

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