Objective To evaluate the effect of Ulinastatin against gastrointestinal complications in patients with septic shock. Methods Seventy-six patients with septic shock were randomly divided into two groups: A group was treatment group(n=38), B group was control group(n=38). All patients in two groups were treated according the Guardline of 2004 rescueing severe septic shock. The patients in group A were received Ulinastatin 200000 Units intravenous once every eight hours and continued for one week in addiction. Results In comparison with group B ,the occurrence of toxic ileus ,stress ulcer ,MODS and mortality decreased obviously (P<0.05) in group A. Conclusion Tryspin inhibitors--Ulinastatin can reduce the occurrence of gastroparesis ,toxic ileus , stress ulcer,superinfection , MODS and mortality in patients with septic shock.