Objective:To evaluate the value of positron emission tomography/comuted tomography (PET/CT) on the diagnosis of pancreatic carcinoma.Methods:A retrospective analysis was performed on 66 cases of patients having pancreatic neoplasm and pancreatitis,all proved by surgery and pathology or clinical diagnosis, and all did PET/CT imaging.Images were interpreted and compared with the histopathologic findings at surgery or with clinical follow up findings.The sensitivity, specificity and accuracy of PET/CT on the diagnosis of pancreatic carcinoma were analyzed. Results: In the 66 cases of pancreatic lesions ,there are 48 patients with pancreatic malignant neoplasm and 18 patients with benign lesions.Forty eight patients had pancreatic malignant neoplasm ,among whom 45 were pancreatic carcinomas,3 were metastatic carcinoma of pancreas.18 patients had benign lesions,among whom 9 were cystadenoma,5 were inflammatory pancreatic tumor, 2 were cystis ,1 was insulinoma and pancreatic lithiasis. The sensitivity of PET/CT on the diagnosis of pancreatic carcinoma was 100%,the specificity was 66.7% and the accuracy was 90.9%. Conclusion: PET/CT is a reliable and effective method to the diagnosis of pancreatic carcinomas.