缺氧诱导因子-1α在宫颈癌组织中的表达及其与微血管生成的关系-现代医学

缺氧诱导因子-1α在宫颈癌组织中的表达及其与微血管生成的关系

作者：王燕吴强

单位：南京医科大学; 南京医科大学附属第二医院妇产科;

关键词：缺氧诱导因子-1α 血管内皮生长因子血管生成宫颈癌宫颈上皮内瘤样病变免疫组织化学

分类号：

出版年·卷·期（页码）：2009·37·第四期（270-273）

摘要：

目的探讨缺氧诱导因子-1α(HIF-1α)、血管内皮生长因子(VEGF)在宫颈癌中的表达及其与微血管生成的关系。方法应用免疫组织化学技术分别检测43例宫颈癌、32例宫颈上皮内瘤样病变(CIN)和43例正常宫颈组织中的HIF-1α、VEGF的表达及微血管密度(MVD)。结果HIF-1α、VEGF、MVD在正常宫颈组织、CIN、宫颈癌中的阳性表达率均依次升高,3组之间比较均有显著性差异(均P<0.01);HIF-1α的表达与VEGF呈正相关(P<0.05),VEGF的表达与MVD也呈正相关(P<0.05)。结论HIF-1α、VEGF及MVD在宫颈癌的发生、发展中起重要作用,HIF-1α在宫颈癌组织中呈高表达,并通过VEGF表达促进肿瘤血管形成。HIF-1α可能成为治疗宫颈癌新的靶基因。

Objective To explore the expressions of hypoxia-induced factor-1α(HIF-1α) and vascular endothelial growth factor(VEGF) in cervical carcinoma.The relationships between the expression of the said two structures and micro blood vessels formation are also discussed.Methods Immunohistochemistry method was performed to examine the expression of HIF-1α,VEGF and micro vascular density(MVD)in 43 cases of tissues of cervical carcinoma,32 cases of cervical intra-epithelial neoplasia(CIN) cervical tissues and 43 cases ...

参考文献：

[1]	Zhong H,Sem enza GL,S imons JW,et a. l Up-regu lation of hy-poxia-inducib le factor 1 alpha is an early event in prostate carcino-genesis .Cancer D etect Prev. 2004, 28(2) :88-93 .
[2]	Bracken CP, Whitelaw ML, Peet DL. The hypoxia-inducible factors: Key transcriptional regulators of hypoxic responses .Cell Mol Life Sci, 2003, 60(7) :1376-1393 .
[3]	Semenza,GL. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1 .Annu Rev Cell Dev Biol, 1999, 15 :551~578 .
[4]	Ryan HE,Poloni M,McNulty W,et al. Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth[J] .Cancer Res, 2000, 60 (15) :4010-4015 .
[5]	Jones A, Fujiyama C, Blanche C, et al. Relation of vascular endothelial growth factor production to expression and regulation of hypoxia-inducible factor-1 alpha and hypoxia-inducible factor-2 alpha in human bladder tumors and cell lines .Clinical Cancer Res, 2001, 7 :6417~6423 .
[6]	Semenza GL. Hypoxia inducible factor 1: oxygen homeostasis and disease pathophysiology [J] .Trends Mol Med, 2001, 7 (8) :345-350 .
[7]	Wenger RH. Cellular adaptation to hypoxia:O2-sensing protein hydroxylases,hypoxia-inducible transcription factors,and O2-regulated gene expression .FASEB J, 2002, 16 (10) :1151-1162 .
[8]	Chan DA,Suthin PD,Denko NC,et al. Role of polyl hydroxylation in oncogenically stabilized hypoxia-inducible factor 1α .Biol Chem, 2002, 277 (42) :40112-40117 .
[9]	Kerbel RS Tumor angiogenesis: past. present and the near future .Carcinogenesis, 2000, 21(3) :505-515 .

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录