胶质瘤手术患者衰弱、自我同情与生活质量的相关性分析-现代医学

胶质瘤手术患者衰弱、自我同情与生活质量的相关性分析

单位：南京医科大学附属脑科医院神经外科, 江苏南京 210029

分类号：R739.4

出版年·卷·期（页码）：2025·53·第十一期（1763-1769）

摘要：

目的：探究胶质瘤手术患者衰弱、自我同情与生活质量的相关性。方法：采取便利抽样法，选取2023年5月至2024年10月于本院接受手术治疗的164例胶质瘤患者。术后出院前1 d采用一般资料调查问卷收集患者基线人口学资料及疾病治疗相关资料，采用中文版格列宁根衰弱指标量表(GFI)评估衰弱情况，以中文版自悯量表(SCS)评估自我同情水平。术后随访6个月，采用中文版癌症患者生命质量测定量表(FACT-G)评估生活质量。应用Pearson相关性分析衰弱、自我同情与胶质瘤手术患者生活质量的相关性，采用多元线性回归分析生活质量的影响因素。结果：胶质瘤手术患者FACT-G总分为(78.08±12.85)分，SCS总分为(87.82±8.72)分，GFI总分为(5.52±1.83)分。Pearson相关性分析显示，GFI得分与FACT-G得分呈负相关(r=-0.534，P＜0.01)，SCS得分与FACT-G得分呈正相关(r=0.507，P＜0.01)。单因素分析显示，年龄≤60岁、大专及以上文化程度、肿瘤直径≤4 cm、病理分级为低级别、手术方式为全切、术前卡氏功能状态(KPS)评分＞70分的胶质瘤手术患者FACT-G得分较高(P＜0.05)。多元线性回归分析显示，年龄＞60岁、GFI得分升高对胶质瘤手术患者生活质量具有负向预测作用，全切手术、术前KPS评分＞70分、SCS得分升高具有正向预测作用(P＜0.05)。结论：胶质瘤手术患者生活质量处于中等水平，其中自我同情水平与生活质量水平成显著正相关，衰弱程度与生活质量水平成负相关。年龄、手术方式、术前KPS评分、GFI及SCS得分均是影响胶质瘤手术患者生活质量的重要因素。

Objective: To explore the correlation between frailty, self-compassion and quality of life in patients with glioma surgery. Methods: A total of 164 patients with glioma who underwent surgical treatment at our hospital from May 2023 to Oct. 2024 were selected by convenience sampling method. Baseline demographic data and treatment-related data were collected on the day before discharge using a general information questionnaire. The Chinese version of Groningen frailty indicator(GFI) and the Chinese version of self-compassion scale(SCS) were used to assess frailty status and self-compassion level, respectively. After 6 month follow-up, quality of life was evaluated using the Chinese version of functional assessment of cancer therapy-general(FACT-G). Pearson correlation analysis was used to examine the correlation between frailty, self-compassion and quality of life in patients undergoing glioma surgery. Multiple linear regression was used to analyze the influencing factors of quality of life. Results: The total FACT-G score was 78.08±12.85, the total SCS score was 87.82±8.72, and the total GFI score was 5.52±1.83. Pearson correlation analysis showed that the GFI score was negatively correlated with the FACT-G score(r=-0.534,P<0.01), whereas the SCS score was positively correlated with the FACT-G score(r=0.507,P<0.01). Univariate analysis showed that glioma-surgery patients who were ≤60 years, had a college degree or higher, presented with a tumor diameter ≤4 cm, low-grade pathology, gross-total resection, and a preoperative Karnofsky performance status(KPS) score >70 had significantly higher FACT-G scores(P<0.05). Multiple linear regression analysis showed that age >60 years and increased GFI score had negative predictive effects on quality of life in patients undergoing glioma surgery, while gross-total resection, preoperative KPS score >70, and increased SCS score had positive predictive effects(P<0.05). Conclusion: The quality of life of patients undergoing glioma surgery is moderate. Self-compassion is positively associated with quality of life, whereas frailty is negatively associated. Age, surgical method, preoperative KPS, GFI and SCS scores are all important factors affecting the quality of life of patients undergoing glioma surgery.

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