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异位妊娠诊断相关生物标志物的研究进展
作者:杨晨一  顾敏  陈洁  叶春萍 
单位:南京医科大学附属妇产医院/南京市妇幼保健院 妇产科, 江苏 南京 210006
关键词:异位妊娠 诊断 生物标志物 综述 
分类号:R714.22
出版年·卷·期(页码):2025·44·第六期(1014-1020)
摘要:

异位妊娠(EP)是孕产妇早期死亡的重要原因之一,近年来发病率逐年上升,使得人们意识到早期诊断的重要性,目前临床上,EP的早期诊断主要依赖于超声和血清人绒毛膜促性腺激素(β-hCG)检测,但都存在不足,亟需寻找新的标志物。本文作者综述近年相关研究,重点分析孕酮(P)、激活素A (Activin A)、妊娠相关蛋白A (PPAP-A)、血管内皮生长因子(VEGF)、胎盘生长因子(PIGF)、去整合素金属蛋白酶12(ADAM-12)、MicroRNA (miRNA)和唾液蛋白等标志物的诊断价值。多种标志物有潜力用于EP早期诊断,并且联合检测比单一标志物准确性更高。未来应进一步探索这些标志物的应用,以提高EP的早期诊断准确性和效率。

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