类风湿性关节炎与乳腺癌因果关联：两样本孟德尔随机化研究和荟萃分析-现代医学

类风湿性关节炎与乳腺癌因果关联：两样本孟德尔随机化研究和荟萃分析

单位：山东大学齐鲁医院检验科, 山东济南 250012

分类号：R593.22;R737.9

出版年·卷·期（页码）：2024·52·第十二期（1838-1843）

摘要：

目的：利用两样本孟德尔随机化(TSMR)和荟萃分析的方法探讨类风湿性关节炎(RA)与乳腺癌的因果关系。方法：采用逆方差加权(IVW)、加权中位数、Egger回归、简单模式和加权模式方法，对在线可访问数据集进行TSMR分析，利用EBI数据库进行荟萃分析。结果：正向TSMR (OR=0.947，95%CI 0.914~0.982，P=0.003)和EBI数据库荟萃分析(OR=0.97，95%CI 0.96~0.99)表明，RA与乳腺癌患病风险具有因果关系。采用留一法剔除SNP后，TSMR分析结果稳健。反向TSMR结果表明，乳腺癌与RA不具有因果关系(OR=0.976，95%CI 0.936~1.019，P=0.268)。结论：RA与乳腺癌之间存在负相关因果关系，这为揭示RA与癌症患病风险的关系提供参考。

Objective:To explore the causal relationship between rheumatoid arthritis(RA) and breast cancer by two-sample Mendelian randomization(TSMR) and Meta-analysis.Methods:Inverse variance weighting(IVW), weighted median, Egger regression, simple mode and weighted mode methods were used to perform TSMR analysis on online accessible data sets, and Meta-analysis was conducted using the EBI database.Results:Positive TSMR(OR=0.947, 95%CI 0.914-0.982, P=0.003) and EBI database Meta-analysis(OR=0.97, 95%CI 0.96-0.99), indicating that RA had a causal relationship with the risk of breast cancer. After using the leave-one-out method to eliminate SNPs, the TSMR analysis results were robust. The reverse TSMR results showed that there was no causal relationship between breast cancer and RA(OR=0.976, 95%CI 0.936-1.019, P=0.268).Conclusion: There is a negative causal relationship between RA and breast cancer, which provides a reference for revealing the relationship between RA and the risk of cancer.

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