咖啡摄入量与心血管疾病发病风险的剂量-反应Meta分析-现代医学

咖啡摄入量与心血管疾病发病风险的剂量-反应Meta分析

单位：1. 山东第二医科大学护理学院, 山东潍坊 261053;
2. 山东第一医科大学(山东省医学科学院) 护理学院, 山东泰安 271016;
3. 山东第一医科大学第一附属医院(山东省千佛山医院) 护理部, 山东济南 250014

分类号：R543

出版年·卷·期（页码）：2024·52·第十二期（1822-1838）

摘要：

目的：评价咖啡摄入量与心血管疾病发病风险之间的剂量-反应关系。方法：系统检索PubMed、Embase、Cochrane Library、Web of Science、中国知网、中国生物医学文献数据库、维普数据库和万方数据库，收集咖啡摄入量与心血管疾病发病风险关系的相关研究，检索时限为2000年1月至2023年12月。由两名研究者独立筛选文献、提取数据并进行文献质量评价，采用Stata 18.0软件分析咖啡摄入量与心血管疾病发病风险的剂量-反应关系。结果：本研究最终共纳入30篇队列研究，涉及2 079 727名研究对象。本研究将125 mL定义为1杯咖啡。传统Meta分析显示，与不喝或几乎不喝咖啡的人群相比，喝咖啡的人群心血管疾病发病风险降低5%(RR=0.95，95% CI0.92~0.98)。剂量-反应Meta分析显示，咖啡摄入量与心血管疾病发病风险存在非线性剂量-反应关系(P=0.01)；与不摄入咖啡的人群相比，每天摄入1～6杯咖啡的人群心血管疾病发病风险显著降低，分别为(1杯·d^-1：RR=0.97，95% CI0.95~0.98)、(2杯·d^-1：RR=0.94，95% CI 0.92~0.96)、(3杯·d^-1：RR=0.92，95% CI0.90~0.95)、(4杯·d^-1：RR=0.92，95% CI 0.89~0.95)、(5杯·d^-1：RR=0.93，95% CI0.89~0.96)、(6杯·d^-1：RR=0.94，95% CI0.90~0.98)。结论：适量饮用咖啡可以降低冠心病、心肌梗死和心力衰竭等心血管疾病的发病风险。

Objective:To evaluate the dose-response relationship between coffee intake and the risk of cardiovascular disease.Methods: We systematically searched PubMed，Embase，Cochrane Library，Web of Science，China National Knowledge Infrastructure，Chinese Biomedical Literature Database，VIP database and Wanfang database to collect relevant studies on the relationship between coffee intake and cardiovascular disease risk. The search period was from January 2000 to December 2023. Two researchers independently screened literature，extracted data and evaluated literature quality. The dose-response relationship between coffee intake and cardiovascular disease risk was analyzed using Stata 18.0 software. Results:A total of 30 cohort studies were included in this study，involving 2 079 727 subjects. Our study defines 1 cup of coffee as 125 mL.Traditional Meta-analyses showed that coffee drinkers had a 5% lower risk of cardiovascular disease compared with those who drank no or little coffee (RR=0.95，95%CI0.92-0.98). The dose-response Meta-analysis showed that there was a nonlinear dose-response relationship between coffee intake and cardiovascular disease risk(P=0.01). Compared with non-coffee drinkers，those who consumed 1 to 6 cups of coffee per day had significantly lower risk of cardiovascular disease(1 cup·d^-1: RR=0.97，95%CI0.95-0.98)，(2 cup·d^-1: RR=0.94，95%CI0.92-0.96)，(3 cup·d^-1: RR=0.92，95%CI0.90-0.95)，(4 cup·d^-1: RR=0.92，95%CI0.89-0.95)，(5 cup·d^-1: RR=0.93，95%CI0.89-0.96)，and(6 cup·d^-1: RR=0.94，95%CI0.90-0.98). Conclusion: Moderate coffee consumption can reduce the risk of cardiovascular diseases such as coronary heart disease，myocardial infarction and heart failure.

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