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壳聚糖水凝胶在口腔颌面部骨组织工程中的应用
作者:杨力菲1  罗春妮1  桑圣琦1 2  陆萌萌1 2 
单位:1. 复旦大学附属口腔医院, 上海市口腔医院 口腔外科, 上海 200001;
2. 上海市颅颌面发育与疾病重点实验室, 上海 200002
关键词:骨组织工程 壳聚糖水凝胶 骨再生 生物支架 生长因子 综述 
分类号:R782
出版年·卷·期(页码):2024·52·第十一期(1804-1808)
摘要:

口腔颌面部骨组织是行使口腔功能和支持外貌轮廓的结构基础,而针对外伤、疾病导致的骨缺损的修复一直是临床研究的热点问题。壳聚糖水凝胶是理想的组织工程材料,具有良好的生物相容性、广谱抗菌性和可降解性,并可复合生物活性材料、生长因子及药物等促进骨组织再生。本文作者就壳聚糖水凝胶在口腔颌面部骨组织工程中的应用进行综述,为其未来应用及研发提供参考。

参考文献:

[1] BOSE S,ROY M,BANDYOPADHYAY A.Recent advances in bone tissue engineering scaffolds[J].Trends Biotechnol,2012,30(10):546-554.
[2] LICHTE P,PAPE H C,PUFE T,et al.Scaffolds for bone healing:concepts,materials and evidence[J].Injury,2011,42(6):569-573.
[3] UNAL S,OKTAR F N,MAHIROGULLARI M,et al.9-Bone structure and formation:a new perspective[J].Elsevier Ser Adv Ceram Mater,2021:175-193.
[4] YARIMITSU S,SASAKI S,MURAKAMI T,et al.Evaluation of lubrication properties of hydrogel artificial cartilage materials for joint prosthesis[J].Biosurf Biotribol,2016,2(1):40-47.
[5] COLE J H,MARJOLEIN C H,VAN DER MEULEN.Whole bone mechanics and bone quality[J].Clin Orthop Relat Res,2011,469(8):2139-2149.
[6] WU S,LIU X,YEUNG K W,et al.Biomimetic porous scaffolds for bone tissue engineering[J].Mater Sci Eng R,2014,80:1-36.
[7] KANCHAN M,SUDIP D,KRISHNA P,et al.Preparation and evaluation of gelatin-chitosan-nanobioglass 3d porous scaffold for bone tissue engineering[J].Int J Biomater,2016,2016:9825659.
[8] MATHEWS S,GUPTA P K,BHONDE R,et al.Chitosan enhances mineralization during osteoblast 5 associated genes[J].Cell Prolif,2011,44(6):537-549.
[9] KIM H D,LEE E A,AN Y,et al.Chondroitin sulfate-based biomineralizing surface hydrogels for bone tissue engineering[J].ACS Appl Mater Interfaces,2017,9(26):21639-21650.
[10] HWAN D K,HAE L J,HYO Y A,et al.Biomimetic whitlockite inorganic nanoparticles-mediated in situ remodeling and rapid bone regeneration[J].Biomaterials,2017,112:31-43.
[11] 刘莉,高亚男,纪宏宇,等.壳聚糖类水凝胶在组织工程中的应用[J].医药导报,2016,35(9):982-986.
[12] YU P,BAO R,SHI X,et al.Self-assembled high-strength hydroxyapatite/graphene oxide/chitosan composite hydrogel for bone tissue engineering[J].Carbohydr Polym,2017,155:507-515.
[13] LI X,YANG Z,FANG L,et al.Hydrogel composites with different dimensional nanoparticles for bone regeneration[J].Macromol Rapid Commun,2021,42(20):e2100362.
[14] CHAI Q,JIAO Y,YU X.Hydrogels for biomedical applications:their characteristics and the mechanisms behind them[J].Gels,2017,3(1):6.
[15] DHIVYA S,SARAVANAN S,SASTRY T P,et al.Nanohydroxyapatite-reinforced chitosan composite hydrogel for bone tissue repair in vitro and in vivo[J].J Nanobiotechnol,2015,13(1):40.
[16] CHEN Y,ZHANG F,FU Q,et al.In vitro proliferation and osteogenic differentiation of human dental-pulp stem cells in injectable thermosensitive chitosan/β-glycerophosphate/hydroxyapatite hydrogel[J].J Biomater Appl,2016,31(3):317-327.
[17] CHANG Y L,STANFORD C M,KELLER J C.Calcium and phosphate supplementation promotes bone cell mineralization:implications for hydroxyapatite(ha)‐enhanced bone formation[J].J Biomed Mater Res,2000,52(2):270-278.
[18] 李鑫平,崔秋菊,曾曙光,等.β-磷酸三钙/壳聚糖水凝胶改性对牙髓干细胞生长与矿化的影响[J].中国组织工程研究,2021,25(22):3493-3499.
[19] LUCA L,ROUGEMONT A,WALPOTH B H,et al.Injectable rhbmp-2-loaded chitosan hydrogel composite:osteoinduction at ectopic site and in segmental long bone defect[J].J Biomed Mater Res A,2011,96(1):66-74.
[20] DASGUPTA S,MAJI K,NANDI S K.Investigating the mechanical,physiochemical and osteogenic properties in gelatin-chitosan-bioactive nanoceramic composite scaffolds for bone tissue regeneration:in vitro and in vivo[J].Mater Sci Eng C,2018,94:713-728.
[21] MOREIRA C D,CARVALHO S M,FLORENTINO R M,et al.Injectable chitosan/gelatin/bioactive glass nanocomposite hydrogels for potential bone regeneration:in vitro and in vivo analyses[J].Int J Biol Macromol,2019,132:811-821.
[22] WU J,ZHENG K,HUANG X,et al.Thermally triggered injectable chitosan/silk fibroin/bioactive glass nanoparticle hydrogels for in-situ bone formation in rat calvarial bone defects[J].Acta Biomater,2019,91:60-71.
[23] 王勇,姚子昂,吴海歌.壳聚糖温敏水凝胶在骨组织工程中的研究进展[J].化工新型材料,2022,50(S1):13-19.
[24] WANG L,STEGEMANN J P.Thermogelling chitosan and collagen composite hydrogels initiated with β-glycer ophosphate for bone tissue engineering[J].Biomaterials,2010,31(14):3976-3985.
[25] LU H,LU T,CHEN C,et al.Development of nanocomposite scaffolds based on biomineralization of N,O-carboxymethyl chitosan/fucoidan conjugates for bone tissue engineering[J].Int J Biol Macromol,2018,120(PB):2335-2345.
[26] VERMA N K,KAR A K,SINGH A,et al.Control release of adenosine potentiate osteogenic differentiation within a bone integrative egcg-g-nocc/collagen composite scaffold toward guided bone regeneration in a critical-sized calvarial defect[J].Biomacromolecules,2021,22(7):3069-3083.
[27] YU Y,SUN Y,ZHOU X,et al.Ag and peptide codecorate polyetheretherketone to enhance antibacterial property and osteogenic differentiation[J].Colloids Surf B Biointerfaces,2021,198:111492.
[28] SONG J,LI T,GAO J,et al.Building an aprismatic enamel-like layer on a demineralized enamel surface by using carboxymethyl chitosan and lysozyme-encapsulated amorphous calcium phosphate nanogels[J].J Dent,2021,107(prepublish):103599.
[29] 凡亚强.负载BMP-2的壳聚糖温敏水凝胶在种植体周围骨修复中的应用研究[D].长春:吉林大学,2020.
[30] 刁兆峰.HA/β-TCP/CS/MC可注射组织工程骨用于兔上颌窦提升的实验研究[D].乌鲁木齐:新疆医科大学,2019.
[31] BEATRIZ S,BORGES C,THAIS S,et al.Effect of dexamethasone as osteogenic supplementation in in vitro osteogenic differentiation of stem cells from human exfoliated deciduous teeth[J].J Mater Sci Mater Med,2021,32(1):1.
[32] HERRON C,HASTINGS C L,HERRONRICE C,et al.A thermoresponsive chitosan/β-glycerophosphate hydrogel for minimally invasive treatment of critical limb ischaemia[J].Polymers(Basel),2021,13(20):3568.
[33] QIN H,WANG J,WANG T,et al.Preparation and characterization of chitosan/β-glycerophosphate thermal-sensitive hydrogel reinforced by graphene oxide[J].Front Chem,2018,6:565.
[34] ZANG S,MU R,CHEN F,et al.Injectable chitosan/β-glycerophosphate hydrogels with sustained release of bmp-7 and ornidazole in periodontal wound healing of class iii furcation defects[J].Mater Sci Eng C,2019,99:919-928.
[35] NIRANJAN R,KOUSHIK C,SARAVANAN S,et al.A novel injectable temperature-sensitive zinc doped chitosan/β-glycerophosphate hydrogel for bone tissue engineering[J].Int J Biol Macromol,2013,54:24-29.
[36] SU W,CHOU W,CHOU C.Osteoblastic differentiation of stem cells from human exfoliated deciduous teeth induced by thermosensitive hydrogels with strontium phosphate[J].Mater Sci Eng C Mater Biol Appl,2015,52:46-53.
[37] SARAVANAN S,VIMALRAJ S,ANURADHA D.Chitosan based thermoresponsive hydrogel containing graphene oxide for bone tissue repair[J].Biomed Pharmacother,2018,107:908-917.
[38] BUSH J R,LIANG H,DICKINSON M,et al.Xylan hemicellulose improves chitosan hydrogel for bone tissue regeneration[J].Polym Adv Technol,2016,27(8):1050-1055.
[39] FAIKRUA A,WITTAYA-AREEKUL S,OONKHANOND B,et al.A thermosensitive chitosan/corn starch/β-glycerol phosphate hydrogel containing TGF-β1 promotes differentiation of MSCs into chondrocyte-like cells[J].Tissue Eng Regen Med,2014,11(5):355-361.
[40] YAGHOBEE S,PANJNOUSH M,CHOKAMI R,et al.Effect of simvastatin on bone regeneration:a histologic and histomorphometric analysis[J].Oral Maxillofac Surg,2020,78(6):927-934.
[41] PETIT C,BATOOL F,STUTZ C,et al.Development of a thermosensitive statin loaded chitosan-based hydrogel promoting bone healing[J].Int J Pharm,2020,586(prepublish):119534.
[42] IILAYÖZDOAN A,AKCA G,ŞENEL S.Development and in vitro evaluation of chitosan based system for local delivery of atorvastatin for treatment of periodontitis[J].Eur J Pharm Sci,2018,124:208-216.
[43] IILAY ÖZDOAN A,LARSLAN Y,KÖSEMEHMETOLU K,et al.In vivo evaluation of chitosan based local delivery systems for atorvastatin in treatment of periodontitis[J].Int J Pharm,2018,550(1-2):470-476.
[44] 陈东.甲硝唑羧甲基壳聚糖凝胶等4种试药治疗大鼠干槽症的白细胞介素-10表达分析[J].中国药物与临床,2016,16(5):652-654.
[45] 陈东.甲硝唑羧甲基壳聚糖凝胶等4种试药治疗大鼠干槽症模型的TUNEL分析[J].山西医药杂志,2016,45(11):1263-1264.
[46] 陈东,陈红,周焱一,等.甲硝唑羧甲基壳聚糖凝胶对大鼠牙周炎模型破骨细胞和前列腺素E_2的影响[J].山西医药杂志,2016,45(12):1392-1395.
[47] 陈东,王立津.白介素6在甲硝唑羧甲基壳聚糖凝胶治疗大鼠牙周炎中的变化[J].河北医药,2023,45(15):2266-2270,2276.
[48] 陈东,周焱祎.白介素17A在甲硝唑羧甲基壳聚糖凝胶治疗大鼠牙周炎过程中的变化[J].山西医科大学学报,2022,53(8):1017-1024.
[49] 陈东,周焱祎.甲硝唑羧甲基壳聚糖凝胶治疗大鼠牙周炎过程中白介素-1β的变化[J].中国煤炭工业医学杂志,2022,25(5):453-461.
[50] 翁蔚宗.碳纳米材料治疗开放骨折后感染性骨缺损及伤口疤痕的研究[D].上海:第二军医大学,2017.
[51] 张超.不同自体骨颗粒Ⅰ期清创植骨治疗感染性骨缺损疗效的研究[D].兰州:甘肃中医药大学,2018.
[52] PAJARES C,WAGLEY Y,MADU-KA C,et al.Silverdoped bioactive-glass particles for in vivo bone tissue regeneration and enhanced methicillin-resistant staphylococcus aureus(mrsa) inhibition[J].Mater Sci Eng:C,2020,120(prepublish):111693.
[53] 王方阔,于美爱,谢冬,等.综合设计性实验的开发及教学实践[J].天津化工,2021,35(6):151-153.
[54] CAI B,ZOU Q,ZUO Y,et al.An injectable gel constructs with regenerative and anti-infective dual effects based on assembled chitosan microspheres[J].ACS Appl Mater Interfaces,2018,10(30):25099-25112.
[55] 宋淼.小檗碱-壳聚糖温敏性水凝胶的制备及其对犬感染性骨缺损的治疗作用[D].哈尔滨:东北农业大学,2024.
[56] SUNGKHAPHAN P,THAVORNYUTIKARN B,KAEWKONG P,et al.Antibacterial and osteogenic activities of clindamycin-releasing mesoporous silica/carboxymethyl chitosan composite hydrogels[J].R Soc Open Sci,2021,8(9):210808.
[57] HERFORD A,MILLER M,SIGNORINO F.Maxillofacial defects and the use of growth factors[J].Oral Maxillofac Surg Clin North Am,2017,29(1):75-88.
[58] CHEN R,WANG J,LIU C.Biomaterials act as enhancers of growth factors in bone regeneration[J].Adv Funct Mater,2016,26(48):8810-8823.
[59] NEWMAN M,BENOIT D.Local and targeted drug delivery for bone regeneration[J].Curr Opin Biotechnol,2016,40:125-132.
[60] 于凤麟.多功能改性壳聚糖自愈合水凝胶修复牙槽骨损伤的研究[D].广州:暨南大学,2020.
[61] SIAILI M,CHATZOPOULOU D,GILLAM D G.An overview of periodontal regenerative procedures for the general dental practitioner[J].Saudi Dent J,2018,30(1):26-37.

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