异基因造血干细胞移植治疗再生障碍性贫血-阵发性睡眠性血红蛋白尿2例-现代医学

异基因造血干细胞移植治疗再生障碍性贫血-阵发性睡眠性血红蛋白尿2例

单位：1. 涟水县人民医院血液科, 江苏涟水 223400;
2. 东南大学附属中大医院血液科, 江苏南京 210009

分类号：R551.3

出版年·卷·期（页码）：2024·52·第十一期（1765-1767）

摘要：

目的: 探讨临床有效治疗再生障碍性贫血-阵发性睡眠性血红蛋白尿(AA-PNH)的方法。方法: 回顾性随访分析2例AA-PNH患者治疗的临床资料。结果: 2例AA-PNH患者行造血干细胞移植(HSCT)后未出现明显的移植物抗宿主病(GVHD)；出院后行血常规监测，输血依赖性逐渐减轻，目前能脱离输血依赖，骨髓造血功能逐渐恢复。结论: 临床治疗AA-PNH的方法多样，但经过对比HSCT效果较好。

Objective: To explore effective clinical treatments for aplastic anemia-paroxysmal nocturnal hemoglobinuria(AA-PNH). Methods: Clinical data of two AA-PNH patients were reviewed retrospectively. Results: Two patients who underwent hematopoietic stem cell transplantation(HSCT) had no obvious GVHD during the course of the disease. Blood routine monitoring was performed after discharge, and the dependence on blood transfusion was reduced little by little. They are now able to discontinue blood transfusion and their hematopoietic function is gradually recovering. Conclusion: There are various clinical treatments for AA-PNH, but HSCT has superior to others after comparison.

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