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矮身材患儿使用不同剂型生长激素治疗的效果及生活质量评估
作者:朱艳丽1 2  姜玉章3  周文娣1 
单位:1. 徐州医科大学淮安临床学院 儿科, 江苏 淮安 223300;
2. 南京医科大学康达学院附属涟水人民医院 儿科, 江苏 淮安 223400;
3. 徐州医科大学淮安临床学院 检验科, 江苏 淮安 223300
关键词:矮身材 患儿 生长激素 生活质量 
分类号:R725.8
出版年·卷·期(页码):2024·52·第十期(1546-1551)
摘要:

目的: 观察矮身材患儿使用长、短效剂型生长激素治疗的效果及对生活质量的影响,为临床治疗方案的选择提供依据。方法: 采用密封信封法将入组的150例矮身材患儿随机分为对照组、长效治疗组及短效治疗组。对照组予规范的健康生活指导及营养支持治疗;长效治疗组每周1次皮下注射长效生长激素;短效治疗组每日1次皮下注射短效生长激素。连续治疗6个月,对3组患儿的临床疗效和生活质量进行评估。结果: 治疗6个月后,3组患儿的身高、身高标准差积分(HtSDS)、胰岛素样生长因子1(IGF-1)均较治疗前有所升高(均P<0.05);长、短效治疗组身高,HtSDS,IGF-1明显高于对照组(P<0.05);但长、短效治疗组之间各项数值差异均无统计学意义(均P>0.05)。3组患儿在治疗前后,甲状腺功能和空腹血糖值无明显变化,均维持在正常范围内(P>0.05)。与治疗前相比,对照组治疗后的生活质量差异无统计学意义(P<0.05);长、短效治疗组患儿生活质量得分有所上升,且均高于对照组(均P<0.05);但长、短效治疗组之间生活质量评分差异均无统计学意义(均P>0.05)。结论: 长、短效剂型生长激素治疗均同样有效改善矮身材患儿的身高及生活质量。

Objective: To compare the efficacy of long-acting and short-acting growth hormone therapies and their impact on the quality of life in children with short stature, providing a basis for clinical treatment selection. Methods: 150 children with short stature were randomly divided into the control group, the long-acting treatment group and the short-acting treatment group using the sealed-envelope method. The control group received standardized healthy life guidance and nutritional support treatment. The long-acting treatment group received subcutaneous injection of long-acting growth hormone once a week.The short-acting treatment group received subcutaneous injection of short-acting growth hormone once a day. The clinical efficacy and quality of life of the three groups were evaluated after 6 months of continuous treatment. Results: After 6 months, height, height standard deviation score(HtSDS), and insulin-like growth factor 1(IGF-1) of the three groups increased compared with those before treatment(all P<0.05),the long-and short-acting groups showed significantly greater improvements than those of the control group(all P<0.05).However,there were with no significant differences between the two treatment groups(all P>0.05). Thyroid function and fasting blood glucose remained unchanged and within normal limits(all P>0.05). After treatment, quality of life did not significantly improve in the control group(P>0.05), while it significantly increased in both treatment groups compared to the control(all P<0.05), with no significant difference between the long-and short-acting groups(all P>0.05). Conclusion: Both long-and short-acting growth hormone therapies are equally effective in improving height and quality of life in children with short stature.

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