[1] LI J,RAN C,LI E,et al.Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development[J].Dev Cell,2008,14(1):62-75.
[2] HU T,GHAZARYAN S,SY C,et al.Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia[J].Blood,2012,119(19):4532-4542.
[3] OUSEPH M M,LI J,CHEN H Z,et al.Atypical E2F repressors and activators coordinate placental development[J].Dev Cell,2012,22(4):849-862.
[4] WEIJTS B G,BAKKER W J,CORNELISSEN P W,et al.E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1[J].EMBO J,2012,31(19):3871-3884.
[5] ZALMAS L P,ZHAO X,GRAHAM A L,et al.DNA-damage response control of E2F7 and E2F8[J].EMBO Rep,2008,9(3):252-259.
[6] SUWA A,YOSHINO M,YAMAZAKI C,et al.RMI1 deficiency in mice protects from diet and genetic-induced obesity[J].FEBS J,2010,277(3):677-686.
[7] SUWA A,YOSHINO M,KURAMA T,et al.Glucose regulates RMI1 expression through the E2F pathways in adipose cells[J].Endocrine,2011,40(1):56-61.
[8] SHIMADA Y,KUNINAGA S,ARIYOSHI M,et al.E2F8 promotes hepatic steatosis through FABP3 expression in diet-induced obesity in zebrafish[J].Nutr Metab(Lond),2015,12:17.
[9] CHEN Y,YU D,WANG L,et al.Identification of E2F8 as a transcriptional regulator of gluconeogenesis in primary mouse hepatocytes[J].Biochemistry(Mosc),2019,84(12):1529-1536.
[10] YANG C H,MANGIAFICO S P,WAIBEL M,et al.E2f8 and Dlg2 genes have independent effects on impaired insulin secretion associated with hyperglycaemia[J].Diabetologia,2020,63(7):1333-1348.
[11] KIM J Y,YANG I S,KIM H J,et al.RORα contributes to the maintenance of genome ploidy in the liver of mice with diet-induced nonalcoholic steatohepatitis[J].Am J Physiol Endocrinol Metab,2022,322(2):E118-E131.
[12] LV Y,XIAO J,LIU J,et al.E2F8 is a potential therapeutic target for hepatocellular carcinoma[J].J Cancer,2017,8(7):1205-1213.
[13] HUANG Y L,NING G,CHEN L B,et al.Promising diagnostic and prognostic value of E2Fs in human hepatocellular carcinoma[J].Cancer Manag Res,2019,11:1725-1740.
[14] KENT L N,LEONE G.The broken cycle:E2F dysfunction in cancer[J].Nat Rev Cancer,2019,19(6):326-338.
[15] WU L,TIMMERS C,MAITI B,et al.The E2F1-3 transcription factors are essential for cellular proliferation[J].Nature,2001,414(6862):457-462.
[16] DEGREGORI J,LEONE G,MIRON A,et al.Distinct roles for E2F proteins in cell growth control and apoptosis[J].Proc Natl Acad Sci U S A,1997,94(14):7245-7250.
[17] MAITI B,LI J,DE BRUIN A,et al.Cloning and characterization of mouse E2F8,a novel mammalian E2F family member capable of blocking cellular proliferation[J].J Biol Chem,2005,280(18):18211-18220.
[18] TRIMARCHI J M,LEES J A.Sibling rivalry in the E2F family[J].Nat Rev Mol Cell Biol,2002,3(1):11-20.
[19] OGAWA H,ISHIGURO K,GAUBATZ S,et al.A complex with chromatin modifiers that occupies E2F-and Myc-responsive genes in G0 cells[J].Science,2002,296(5570):1132-1136.
[20] MIZUNO M,MIKI R,MORIYAMA Y,et al.The role of E2F8 in the human placenta[J].Mol Med Rep,2019,19(1):293-301.
[21] GHAZARYAN S,SY C,HU T,et al.Inactivation of Rb and E2f8 synergizes to trigger stressed DNA replication during erythroid terminal differentiation[J].Mol Cell Biol,2014,34(15):2833-2847.
[22] SUN Y,DONG D,XIA Y,et al.YTHDF1 promotes breast cancer cell growth,DNA damage repair and chemoresistance[J].Cell Death Dis,2022,13(3):230.
[23] KONG J,XU S,ZHANG P,et al.Transcription factor E2F8 promotes cisplatin resistance in hepatocellular carcinoma by regulating DNA damage via NUSAP1[J].Int J Toxicol,2023,42(5):420-429.
[24] MORENO E,TOUSSAINT M J M,VAN ESSEN S C,et al.E2F7 is a potent inhibitor of liver tumor growth in adult mice[J].Hepatology,2021,73(1):303-317.
[25] SUN Y,ORAVECZ-WILSON K,MATHEWSON N,et al.Mature T cell responses are controlled by microRNA-142[J].J Clin Invest,2015,125(7):2825-2840.
[26] PARK S A,LIM Y J,KU W L,et al.Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation[J].Nat Commun,2022,13(1):6069.
[27] AKBAY B,GERMINI D,BISSENBAEV A K,et al.HIV-1 Tat activates Akt/mTORC1 pathway and AICDA expression by downregulating its transcriptional inhibitors in B cells[J].Int J Mol Sci,2021,22(4):1588.
[28] GORLA G R,MALHI H,GUPTA S.Polyploidy associated with oxidative injury attenuates proliferative potential of cells[J].J Cell Sci,2001,114(16):2943-2951.
[29] MARGALL-DUCOS G,CELTON-MORIZUR S,COUTON D,et al.Liver tetraploidization is controlled by a new process of incomplete cytokinesis[J].J Cell Sci,2007,120(20):3633-3639.
[30] KUDRYAVTSEV B N,Kudryavtseva M V,Sakuta G A,et al.Human hepatocyte polyploidization kinetics in the course of life cycle[J].Virchows Arch B Cell Pathol Incl Mol Pathol,1993,64(6):387-393.
[31] SEGUIN L,LIOT C,MZALI R,et al.CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2,MgcRacGAP,and MKLP1 in S phase[J].Mol Cell Biol,2009,29(2):570-581.
[32] QI Q R,ZHAO X Y,ZUO R J,et al.Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization[J].Cell Cycle,2015,14(12):1842-1858.
[33] BUDHAVARAPU V N,WHITE E D,MAHANIC C S,et al.Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation[J].Cell Cycle,2012,11(10):2030-2038.
[34] DI STEFANO L,JENSEN M R,HELIN K.E2F7,a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes[J].EMBO J,2003,22(23):6289-6298.
[35] LEONE G,SEARS R,HUANG E,et al.Myc requires distinct E2F activities to induce S phase and apoptosis[J].Mol Cell,2001,8(1):105-113.
[36] WESTENDORP B,MOKRY M,GROOT KOERKAMP M J A,et al.E2F7 represses a network of oscillating cell cycle genes to control S-phase progression[J].Nucleic Acids Res,2012,40(8):3511-3523.
[37] BOEKHOUT M,YUAN R,WONDERGEM A P,et al.Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression[J].EMBO Rep,2016,17(3):414-427.
[38] LOGAN N,GRAHAM A,ZHAO X,et al.E2F-8:an E2F family member with a similar organization of DNA-binding domains to E2F-7[J].Oncogene,2005,24(31):5000-5004.
[39] YAO G,LEE T J,MORI S,et al.A bistable Rb-E2F switch underlies the restriction point[J].Nat Cell Biol,2008,10(4):476-482.
[40] YE L,GUO L,HE Z,et al.Upregulation of E2F8 promotes cell proliferation and tumorigenicity in breast cancer by modulating G1/S phase transition[J].Oncotarget,2016,7(17):23757-23771.
[41] ZHENG J,HUANG J,XIA J,et al.Transcription factor E2F8 is a therapeutic target in the basal-like subtype of breast cancer[J].Front Oncol,2023,13:1038787.
[42] LIN Q.MicroRNA-1-3p affects lung adenocarcinoma progression through E2F8 and regulating NF-кB pathway[J].Cytokine,2022,156:155922.
[43] LEE S,PARK Y R,KIM S H,et al.Geraniol suppresses prostate cancer growth through down-regulation of E2F8[J].Cancer Med,2016,5(10):2899-2908.
[44] HAN Z,MO R,CAI S,et al.Differential expression of E2F transcription factors and their functional and prognostic roles in human prostate cancer[J].Front Cell Dev Biol,2022,10:831329.
[45] YAO H,LU F,SHAO Y.The E2F family as potential biomarkers and therapeutic targets in colon cancer[J].PeerJ,2020,8:e8562.
[46] CHEN R,ZHANG Z,HU B,et al.Identification of the expression and clinical significance of E2F family in clear cell renal cell carcinoma[J].Int J Gen Med,2022,15:1193-1212.
[47] LÜ Y,ZHANG J,LI L,et al.Carcinogenesis effects of E2F transcription factor 8(E2F8) in hepatocellular carcinoma outcomes:an integrated bioinformatic report[J].Biosci Rep,2020,40(2):BSR20193212.
[48] BAIZ D,DAPAS B,FARRA R,et al.Bortezomib effect on E2F and cyclin family members in human hepatocellular carcinoma cell lines[J].World J Gastroenterol,2014,20(3):795-803.
[49] KENT L N,RAKIJAS J B,PANDIT S K,et al.E2f8 mediates tumor suppression in postnatal liver development[J].J Clin Invest,2016,126(8):2955-2969.
[50] IINO K,MITOBE Y,IKEDA K,et al.RNA-binding protein NONO promotes breast cancer proliferation by post-transcriptional regulation of SKP2 and E2F8[J].Cancer Sci,2020,111(1):148-159.
[51] TIAN J,LIN Y,YU J.E2F8 confers cisplatin resistance to ER+breast cancer cells via transcriptionally activating MASTL[J].Biomed Pharmacother,2017,92:919-926.
[52] YU H,ZHANG D,LI Z,et al.E2F transcription factor 8 promotes proliferation and radioresistance in glioblastoma[J].Pathol Res Pract,2020,216(8):153030.
[53] CHEN Y,ZHAO F,CUI D,et al.HOXD-AS1/miR-130a sponge regulates glioma development by targeting E2F8[J].Int J Cancer,2018,142(11):2313-2322.
[54] JIN D H,KIM Y,LEE B B,et al.Metformin induces cell cycle arrest at the G1 phase through E2F8 suppression in lung cancer cells[J].Oncotarget,2017,8(60):101509-101519.
[55] YAN P Y,ZHANG X A.Knockdown of E2F8 suppresses cell proliferation in colon cancer cells by modulating the NF-κB pathway[J].Ann Clin Lab Sci,2019,49(4):474-480.
[56] ZHANG Z,LI J,HUANG Y,et al.Upregulated miR-1258 regulates cell cycle and inhibits cell proliferation by directly targeting E2F8 in CRC[J].Cell Prolif,2018,51(6):e12505.
[57] YANG A P,LIU L G,CHEN M M,et al.Integrated analysis of 10 lymphoma datasets identifies E2F8 as a key regulator in Burkitt's lymphoma and mantle cell lymphoma[J].Am J Transl Res,2019,11(7):4382-4396.
[58] BOURNE C M,MUN S S,DAO T,et al.Unmasking the suppressed immunopeptidome of EZH2-mutated diffuse large B-cell lymphomas through combination drug treatment[J].Blood Adv,2022,6(14):4107-4121.
[59] MORRELL B C,ZHANG L,SCHÜTZ L F,et al.Regulation of the transcription factor E2F8 gene expression in bovine ovarian cells[J].Mol Cell Endocrinol,2019,498:110572.
[60] EOH K J,KIM H J,LEE J W,et al.E2F8 induces cell proliferation and invasion through the epithelial-mesenchymal transition and Notch signaling pathways in ovarian cancer[J].Int J Mol Sci,2020,21(16):5813.
[61] ZHANG M,XU Y,ZHANG Y,et al.E2F8 knockdown suppresses cell proliferation and induces cell cycle arrest via Wnt/β-Catenin pathway in ovarian cancer[J].Chin J Physiol,2023,66(4):266-275.
[62] THURLINGS I,MARTÍNEZ-LÓPEZ L M,WESTENDORP B,et al.Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer[J].Oncogene,2017,36(6):829-839.
[63] WANG H,WANG L,TANG L,et al.Long noncoding RNA SNHG6 promotes proliferation and angiogenesis of cholangiocarcinoma cells through sponging miR-101-3p and activation of E2F8[J].J Cancer,2020,11(10):3002-3012.
[64] CHANG H,SONG J,WU J,et al.E2F transcription factor 8 promotes cell proliferation via CCND1/p21 in esophageal squamous cell carcinoma[J].Onco Targets Ther,2018,11:8165-8173.
[65] LI S,YANG X,LI W,et al.Comprehensive analysis of E2F family members in human gastric cancer[J].Front Oncol,2021,11:625257.
[66] KIM L K,PARK S A,EOH K J,et al.E2F8 regulates the proliferation and invasion through epithelial-mesenchymal transition in cervical cancer[J].Int J Biol Sci,2020,16(2):320-329.
[67] SUN J,SHI R,ZHAO S,et al.E2F8,a direct target of miR-144,promotes papillary thyroid cancer progression via regulating cell cycle[J].J Exp Clin Cancer Res,2017,36(1):40. |
