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涟水某基层医院多发性骨髓瘤患者临床诊治现状
作者:王瑞1  宋慧慧2  卜文宣1  丁荣1  耿新1  杨阳1  徐平1  张建军1  陈宝安2 
单位:1. 涟水县人民医院 血液科, 江苏 淮安 223400;
2. 东南大学附属中大医院 血液科, 江苏 南京 210009
关键词:多发性骨髓瘤 基层医院 硼替佐米 化疗 
分类号:R733.3
出版年·卷·期(页码):2024·52·第七期(1084-1087)
摘要:

目的:分析近5年来涟水县人民医院多发性骨髓瘤患者的诊治现状。方法:回顾2017年11月至2023年8月涟水县人民医院收治的34例多发性骨髓瘤患者资料,根据治疗方法不同分为传统化疗组和新药联合化疗组两组,传统化疗方案由沙利度胺联合地塞米松组成,新药联合化疗由硼替佐米或来那度胺联合传统化疗药物组成。分析患者临床资料,观察两组多发性骨髓瘤患者治疗效果及相关指标变化。结果:治疗后新药联合化疗组总有效率(88.2%)高于传统化疗组(55.9%)(P<0.05);治疗后新药联合化疗组M蛋白、骨髓浆细胞比例、β2微球蛋白水平与传统化疗组相比,下降明显,治疗前后两组指标差值比较,差异有统计学意义(P<0.05);治疗后新药联合化疗组血红蛋白水平上升明显,两组差值比较,差异有统计学意义(P<0.05);治疗后新药联合化疗组尿素氮(BUN)、血肌酐(SCr)、血尿酸(UA)水平明显下降,治疗前后两组BUN、SCr、UA的差值比较,差异有统计学意义(P<0.05)。结论:多发性骨髓瘤患者应用硼替佐米、沙利度胺和地塞米松联合化疗总有效率更高,可显著改善患者肾功能,M蛋白、β2微球蛋白、血红蛋白及浆细胞水平,值得临床应用推广。

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