肠道菌群与甲状腺癌风险的关联：一项多变量孟德尔随机化研究-现代医学

肠道菌群与甲状腺癌风险的关联：一项多变量孟德尔随机化研究

单位：山东第一医科大学第一附属医院肿瘤放疗科, 山东济南 250014

分类号：R736.1

出版年·卷·期（页码）：2024·52·第七期（1057-1063）

摘要：

目的：探索肠道菌群与甲状腺癌之间的潜在因果关系。方法：在IEU Open GWAS数据库中检索有关肠道菌群与甲状腺癌的相关数据，采用逆方差加权法(IVW)作为孟德尔随机化(MR)分析的主要方法，并补充敏感性分析以检查结果的稳健性。 结果：MR结果表明埃格特菌属丰度的升高与甲状腺癌发生风险呈正相关(IVW:OR=3.22，95%CI 1.03~10.02，P=0.043)，裂孢真杆菌属丰度的升高与甲状腺癌发生风险呈负相关(IVW： OR=0.38，95%CI 0.15~0.98，P=0.045)。敏感度分析显示没有反向因果关系、多效性和异质性的证据。结论：裂孢真杆菌属可降低甲状腺癌发病风险，埃格特菌属与甲状腺癌风险增加有关，但可能受饮酒因素干扰。

Objective: To explore the potential causal relationship between intestinal flora and thyroid cancer. Methods: Relevant data on intestinal flora and thyroid cancer were retrieved from the IEU Open GWAS. The inverse-variance weighted(IVW) method was used as the primary approach for Mendelian randomization(MR) analysis, complemented by sensitivity analysis to assess the robustness of the fundings. Results: The MR results showed that an elevated abundance of the genus Eggerthella was positively associated with an increased risk of thyroid cancer(IVW: OR=3.22, 95%CI 1.03-10.02, P=0.043), while a higher abundance of the genus Eubacterium fissicatena was negatively associated with thyroid cancer risk(IVW: OR=0.38，95%CI 0.15-0.98，P=0.045). Sensitivity analysis did not indicate evidence of reverse causality, pleiotropy and heterogeneity. Conclusion: The genus Eubacterium fissicatena may reduce the risk of thyroid cancer, while the genus Eggerthella is associated with an increased risk of thyroid cancer, potentially influenced by alcohol consumption as a confounding factor.

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