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靶向Trop2的抗体药物偶联物治疗晚期肺癌的研究进展
作者:徐岚1  马嘉锋1  张卫平1 2 
单位:1. 浙江中医药大学 第三临床医学院, 浙江 杭州 310000;
2. 浙江中医药大学附属第三医院 肿瘤科, 浙江 杭州 310000
关键词:晚期肺癌 滋养层细胞表面抗原2 抗体药物偶联物 治疗相关不良反应 研究进展 
分类号:R734.2
出版年·卷·期(页码):2024·52·第六期(976-980)
摘要:

抗体药物偶联物(ADC)通过化学接头偶联细胞毒性药物及单克隆抗体,特异性靶向肿瘤细胞,可实现高效杀伤作用。滋养层细胞表面抗原2(Trop2)在肺癌中过表达,且与不良生存结局相关,可作为肺癌治疗的潜在靶标。目前多个Trop2-ADC药物治疗晚期肺癌已进入临床试验阶段且取得了显著疗效。本文旨在回顾总结Trop2-ADC代表性药物治疗晚期肺癌的最新研究进展,并对治疗相关不良反应及处理对策进行展望,以期为后续药物研发与临床应用提供参考。

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