[1] KHALID N,AHMED I,AHMED S.Evaluation of causes of female infertility using ultrasonography in Najran,Saudi Arabia[J].Afr J Reprod Health,2022,26(5):90-95.
[2] 尤小燕，张静华，靳园园，等.多囊卵巢综合征合并不良妊娠与自身免疫调控异常的关系[J].中国临床医生杂志，2023，51(8)：992-996.
[3] RUDNICKA E,SUCHTA K,GRYMOWICZ M,et al.Chronic low grade inflammation in pathogenesis of PCOS[J].Int J Mol Sci,2021,22(7):3789.
[4] GAO Q,MA C,MENG S,et al.Exploration of molecular features of PCOS with different androgen levels and immune-related prognostic biomarkers associated with implantation failure[J].Front Endocrinol(Lausanne),2022,13:946504.
[5] DING J,WANG J,CAI X,et al.Granulocyte colony-stimulating factor in reproductive-related disease:function,regulation and therapeutic effect[J].Biomed Pharmacother,2022,150:112903.
[6] LI T,WU R J,LIANG Q Q,et al.Analysis of serum homocysteine concentration in patients less than 35 years of age with polycystic ovary syndrome and hyperandrogenism[J].Ginekol Pol,2023,94(7):518-523.
[7] QI X,ZHANG B,ZHAO Y,et al.Hyperhomocysteinemia promotes insulin resistance and adipose tissue inflammation in PCOS mice through modulating M2 macrophage polarization via estrogen suppression[J].Endocrinology,2017,158(5):1181-1193.
[8] HUANG X,LUO X,HUANG S,et al.Inhibition of FoxO1 alleviates polycystic ovarian syndrome by reducing inflammation and the immune response[J].Funct Integr Genomics,2024,24(1):6.
[9] LI N,WANG X,WANG X,et al.Upregulation of FoxO1 signaling mediates the proinflammatory cytokine upregulation in the macrophage from polycystic ovary syndrome patients[J].Clin Lab,2017,63(2):301-311.
[10] GAO M,LIU X,DU M,et al.Identification of immune cell infiltration and effective biomarkers of polycystic ovary syndrome by bioinformatics analysis[J].Bmc Pregnancy Childb，2023,23(1):377.
[11] BOIX F,BOLARIN J M,MROWIEC A,et al.CD28 biomarker quantification and expression level profiles in CD4(+)T-lymphocytes in solid organ transplantation[J].Transpl Immunol,2017,42:9-17.
[12] HE S,MAO X,LEI H,et al.Peripheral blood inflammatory-immune cells as a predictor of infertility in women with polycystic ovary syndrome[J].J Inflamm Res,2020,13:441-450.
[13] 李政，邓越，朴春梅，等.多囊卵巢综合征患者血清维生素D水平与免疫功能指标的相关性研究[J].中国医药，2022，17(7)：1047-1051.
[14] FAINARU O,HANTISTEANU S,ROTFARB N,et.al.CD11c+HLADR+dendritic cells are present in human ovarian follicular fluid,and their maturity correlates with serum estradiol levels in response to gonadotropins[J].Fertil Steril，2012,97(3):702-706.
[15] ZHANG T,TIAN F,HUO R,et.al.Detection of dendritic cells and related cytokines in follicular fluid of patients with polycystic ovary syndrome[J].Am J Reprod Immunol,2017,78(3):e12717.
[16] XIAO N,HE K,GONG F,et al.Altered subsets and activities of B lymphocytes in polycystic ovary syndrome[J].J Allergy Clin Immun，2019,143(5):1943-1945.
[17] ASCANI A,TORSTENSSON S,RISAL S,et al.The role of B cells in immune cell activation in polycystic ovary syndrome[J].Elife,2023,12:e86454.
[18] ZHU Q,YAO Y,XU L,et al.Elevated SAA1 promotes the development of insulin resistance in ovarian granulosa cells in polycystic ovary syndrome[J].Reprod Biol Endocrinol,2022,20(1):4.
[19] HAHN A,KNY M,PABLO-TORTOLA C,et al.Serum amyloid A1 mediates myotube atrophy via toll-like receptors[J].J Cachexia Sarcopenia Muscle,2020,11:103-119.
[20] SIMO R,BARBOSA-DESONGLES A,LECUBE A,et al.Potential role of tumor necrosis factor-alpha in downregulating sex hormone-binding globulin[J].Diabetes,2012,61(2):372-382.
[21] XU H,BARNES G T,YANG Q,et al.Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance[J].J Clin Invest,2003,112(12):1821-1830.
[22] HA L X,WU Y Y,YIN T,et al.Effect of TNF-alpha on endometrial glucose transporter-4 expression in patients with polycystic ovary syndrome through nuclear factor-kappa B signaling pathway activation[J].J Physiol Pharmacol,2021,72(6):965-973.
[23] WU Z,FANG L,LI Y,et al.Association of circulating monocyte chemoattractant protein-1 levels with polycystic ovary syndrome:a Meta-analysis[J].Am J Reprod Immunol,2021,86(2):e13407.
[24] QI J,LI J,WANG Y,et al.Novel role of CXCL14 in modulating STAR expression in luteinized granulosa cells:implication for progesterone synthesis in PCOS patients[J].Transl Res,2021,230:55-67.
[25] LIU Y,LIU H,LI Z,et al.The release of peripheral immune inflammatory cytokines promote an inflammatory cascade in PCOS patients via altering the follicular microenvironment[J].Front Immunol,2021,12:685724.
[26] XIE Q,XIONG X,XIAO N,et al.Mesenchymal stem cells alleviate DHEA-induced polycystic ovary syndrome(PCOS) by inhibiting inflammation in mice[J].Stem Cells Int,2019,2019:9782373.
[27] CHUGH R M,PARK H,ESFANDYARI S,et al.Mesenchymal stem cell-conditioned media regulate steroidogenesis and inhibit androgen secretion in a PCOS cell model via BMP-2[J].Int J Mol Sci,2021,22(17):9184.
[28] ZHAO Y,PAN S,WU X.Human umbilical cord mesenchymal stem cell-derived exosomes inhibit ovarian granulosa cells inflammatory response through inhibition of NF-κB signaling in polycystic ovary syndrome[J].J Reprod Immunol,2022,152:103638.
[29] PARK H S,CETIN E,SIBLINI H,et al.Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles to treat PCOS[J].Int J Mol Sci,2023,24(13):11151.
[30] ALBAGHDADI A,FEELEY C A,KAN F.Low-dose tacrolimus prevents dysregulated peri-conceptional ovarian and systemic immune cellular homeostasis in subjects with PCOS[J].Sci Rep-Uk,2019,9(1):6528.
[31] HO S,CLIPSTONE N,TIMMERMANN L,et al.The mechanism of action of cyclosporin A and FK506[J].Clin Immunol Immunopathol,1996,80(3 Pt 2):S40-S45.
[32] NARANJO-GOMEZ M,CLIMENT N,COS J,et al.Tacrolimus treatment of plasmacytoid dendritic cells inhibits dinucleotide(CpG-)-induced tumour necrosis factor-alpha secretion[J].Immunology,2006,119(4):488-498.
[33] LEE S K,PARK M J,JHUN J Y,et al.Combination treatment with metformin and tacrolimus improves systemic immune cellular homeostasis by modulating treg and Th17 imbalance[J].Front Immunol,2020,11:581728.
[34] ROBERTSON S A,MOLDENHAUER L M.Immunological determinants of implantation success[J].Int J Dev Biol,2014,58(2-4):205-217.
[35] LUO M,CHEN Y,PAN X,et al.E.coli Nissle 1917 ameliorates mitochondrial injury of granulosa cells in polycystic ovary syndrome through promoting gut immune factor IL-22via gut microbiota and microbial metabolism[J].Front Immunol,2023,14:1137089.
[36] GAO Z,WANG G,MA X,et al.Troxerutin attenuates insulin resistance via pancreatic IL-22/JAK1/STAT3 signaling activation in dihydrotestosterone-induced polycystic ovary syndrome rats[J].Am J Physiol-Endoc M,2022,323(5):E405-E417.
[37] HASNAIN S Z,BORG D J,HARCOURT B E,et al.Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress[J].Nat Med,2014,20(12):1417-1426.
[38] QI X,YUN C,LIAO B,et al.The therapeutic effect of interleukin-22 in high androgen-induced polycystic ovary syndrome[J].J Endocrinol,2020,245(2):281-289.
[39] QI X,YUN C,SUN L,et al.Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome[J].Nat Med,2019,25(8):1225-1233.
[40] XIAO N,WANG J,WANG T,et al.Metformin abrogates pathological TNF-alpha-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome[J].Elife,2022,11:e74713.
[41] RYSSDAL M,VANKY E,STOKKELAND L,et al.Immunomodulatory effects of metformin treatment in pregnant women with PCOS[J].J Clin Endocr Metab,2023,108(9):e743-e753.
[42] LANG Q,YIDONG X,XUEGUANG Z,et al.ETA-mediated anti-TNF-alpha therapy ameliorates the phenotype of PCOS model induced by letrozole[J].PLoS One,2019,14(6):e217495. |
