绝经女性的潮热症状与冠心病的相关性研究-现代医学

绝经女性的潮热症状与冠心病的相关性研究

单位：1. 南京医科大学附属泰州人民医院心血管内科, 江苏泰州 225300;
2. 柳州市妇幼保健院妇科, 广西柳州 545000;
3. 东南大学附属中大医院妇产科, 江苏南京 210009;
4. 东南大学附属中大医院心内科, 江苏南京 210009

关键词：绝经潮热 Kupperman评分冠心病

分类号：R541.4

出版年·卷·期（页码）：2024·52·第五期（681-687）

摘要：

目的：研究绝经女性的潮热症状与冠心病的相关性。方法：纳入2020年6月至2021年3月于东南大学附属中大医院心内科住院并行冠状动脉造影术(CAG)的40~60岁的绝经女性患者218例，根据CAG结果分为冠心病组(106例)和对照组(112例)。采用更年期症状评分(改良Kupperman评分量表)对更年期症状严重程度进行评估。采用Gensini评分系统评价冠脉病变严重程度。结果：冠心病组的平均改良Kupperman评分显著高于对照组，潮热的发生率也高于对照组，差异均有统计学意义(均P＜0.001)。与对照组相比，冠心病组的潮热频率和持续时间的差异有统计学意义(P＜0.05)。多因素Logistic回归分析结果显示，改良Kupperman评分与诊断冠心病的比例呈正相关(OR=1.12，95%CI 1.07~1.17)。每日潮热频率3~9次和≥10次的患者诊断冠心病的比例是无潮热者的4.60和6.03倍，潮热持续1~3年和＞3年的患者诊断冠心病的比例是无潮热者的4.43和7.55倍，均有统计学意义(均P＜0.05)。线性回归分析结果显示，在冠心病组中，有潮热症状者Gensini评分比无症状者平均高出11.17分(95%CI 2.74~19.60)。结论:绝经期女性的潮热、潮热频发和持续性潮热与冠心病的发生及病变程度具有一定的相关性。

Objective: To investigate the correlation between hot flushes and coronary heart disease in menopausal women. Methods: A total of 218 menopausal female patients aged 40-60 who were admitted to the Department of Cardiology，Zhongda Hospital, Southeast University from June 2020 to March 2021 and underwent coronary angiography(CAG) were enrolled. According to the CAG results, patients were divided into coronary heart disease group(106 cases) and control group(112 cases). The severity of menopausal symptoms was assessed with the modified Kupperman menopausal score. Coronary lesion severity was evaluated by Gensini score. Results: The mean modified Kupperman score in the coronary heart disease group was significantly higher than that in control group, and the incidence of hot flushes was also higher than that in the control group, among which the differences were statistically significant(all P<0.001). There were significant differences in frequency and duration of hot flushes between the coronary heart disease group and the control group(P<0.05). Multivariate Logistic regression analysis showed that the modified Kupperman score was positively correlated with the proportion of coronary heart disease diagnosed(OR=1.12, 95%CI 1.07-1.17). The proportion of patients with 3-9 times and ≥10 times hot flushes per day diagnosed with coronary heart disease was 4.60 and 6.03 times that of patients without hot flashes, the proportion of patients with hot flashes lasting 1-3 years and >3 years who were diagnosed with coronary heart disease was 4.43 and 7.55 times that of patients without hot flashes, all of which were statistically significant(all P<0.05). Linear regression analysis showed that in the coronary heart disease group, the Gensini score of patients with hot flashes was 11.17 points higher than that of asymptomatic patients(95%CI 2.74-19.60). Conclusion: Hot flushes, frequent and persistent hot flushes in menopausal women are correlated with the occurrence and severity of coronary heart diease.

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