视网膜疾病是导致视力受损和失明的主要原因，其致病机制与炎症、氧化应激等多个病理过程有关。这些病理过程可能会引起线粒体功能障碍，并增加线粒体膜的通透性，从而使线粒体DNA漏至细胞质中。cGAS能特异性识别细胞质中的双链DNA，激活cGAS-STING信号通路。研究发现，cGAS-STING信号通路不仅能促进干扰素等免疫调节因子和促炎因子的释放，还可参与自噬、衰老等过程，并且在不同视网膜疾病中扮演着不同的角色。本文作者综述了cGAS-STING信号通路在不同视网膜疾病发生发展中的作用，以期为寻找视网膜疾病的新治疗靶点提供参考。

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