Objective: To explore the effect of micro-video tutorials combined with adaptive training program on the psychological coping styles and negative emotions of nasopharyngeal cancer radiotherapy patients, and to improve the quality of care for these patients.Methods: A total of 126 nasopharyngeal cancer radiotherapy patients admitted to our hospital from January 2021 to February 2023 were included in the study. Patients were randomly divided into a control group(n=63) and an observation group(n=63) based on their admission time. The control group received routine nursing interventions, while the observation group received a combined intervention of micro-video tutorials combined with adaptive training program. Symptom Checklist-90(SCL-90), Hamilton Depression Scale(HAMD), Hamilton Anxiety Scale(HAMA), and Quality of Life in Head and Neck Cancer Patients(QLICP-HN) to assess the psychological coping styles, negative emotions, and quality of life of nasopharyngeal cancer radiotherapy patients.Results: The psychological coping styles score of the observation group(139.52±4.60) was significantly lower than that of the control group(156.13±5.44)(P＜0.05). The difference in the difference in depression and anxiety scores before and after the intervention was statistically significant for patients in the observation and control groups(t=-64.71,-57.77, all P＜0.001). The scores of the four dimensions of psychological functioning, somatic functioning, social functioning, adverse reactions, and co-morbid symptoms of the patients in the observation group were better than the patients in the control group, and the difference was statistically significant(t=-28.71,-28.27,-14.45,-28.80, all P＜0.001).Conclusion: Micro-video tutorial combined with adaptive training program can effectively improve the psychological coping styles and reduce negative emotions in nasopharyngeal cancer radiotherapy patients. After intervention, the patients' quality of life is significantly improved, indicating that this combined nursing intervention model is suitable for clinical promotion and application.