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ERCC6L在肿瘤中的表达和作用
作者:陈宗裕1 2  杨萌3  吕涵1  文周2  向阳2  朱建国3 
单位:1. 贵州医科大学 临床医学院, 贵州 贵阳 550000;
2. 遵义医科大学 临床医学院, 贵州 遵义 563006;
3. 贵州省人民医院 泌尿外科, 贵州 贵阳 550000
关键词:ERCC6L 肿瘤机制 转移 生物标志物 体外 体内 综述 
分类号:R730.2
出版年·卷·期(页码):2024·52·第二期(286-291)
摘要:

ERCC6L是一种新发现的DNA解旋酶,也被称为PLK1相互作用检查点解旋酶(PICH)。它最初在小鼠组织中被鉴定,并属于SNF2蛋白家族的成员之一。作为PLK1的底物,ERCC6L在控制细胞有丝分裂中扮演重要角色。很多研究报道了ERCC6L在肿瘤细胞中异常表达的情况。ERCC6L的异常表达可以通过促凋亡因子抑制细胞增殖或诱导凋亡。然而,由于肿瘤环境的差异和不同肿瘤复杂的调控机制,ERCC6L对不同肿瘤的进展影响也不尽相同。在某些肿瘤中,高表达的ERCC6L可能促进肿瘤的转移,而在其他肿瘤中,高表达的ERCC6L则可能抑制肿瘤的侵袭和转移。越来越多的证据表明,在不同的肿瘤环境中,ERCC6L通过多种复杂的调控机制,在肿瘤的发生、发展和转移过程中发挥着复杂而不同的作用。因此,ERCC6L不仅可能成为一种有用的转移生物标志物,还可能成为研究肿瘤细胞代谢机制和治疗多种类型肿瘤的靶点。本文作者综述了ERCC6L在不同肿瘤中的表达、机制和功能的研究进展,并对ERCC6L在不同肿瘤中的表达情况进行了进一步的分析,为深入理解ERCC6L在肿瘤中的作用机制提供重要的参考。

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