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替妥木单抗治疗甲状腺眼病
作者:王渭鉴  陈慧  王妙 
单位:兰州大学第二医院 内分泌代谢科, 甘肃 兰州 730030
关键词:替妥木单抗 甲状腺眼病 中重度活动性 IgG1单抗 促甲状腺激素受体/胰岛素样生长因子-Ⅰ受体复合体 综述 
分类号:R581; R771.3
出版年·卷·期(页码):2024·52·第二期(281-285)
摘要:

替妥木单抗(Teprotumumab)是完全人源性免疫球蛋白G1(IgG1)的单克隆抗体,与胰岛素样生长因子-Ⅰ受体(IGF-ⅠR)结合,阻断其激活和信息传递。Teprotumumab于2020年1月获得美国食品和药品管理局(FDA)批准,成为首个适用于中重度活动期甲状腺眼病(TED)患者的靶向治疗药物。临床试验表明,相较于安慰剂,Teprotumumab能显著改善患者眼球突出度、临床活动性评分(CAS)及生活质量。其不良反应包括肌肉痉挛、高血糖和耳毒性等。

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