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放射治疗与靶向治疗或免疫治疗联合治疗头颈部鳞癌的研究进展
作者:苏厦露1 2  麻发强1 2  金风1 3 4 
单位:1. 贵州医科大学 临床医学院肿瘤学教研室, 贵州 贵阳 550004;
2. 贵州医科大学第二附属医院 肿瘤科, 贵州 凯里 556000;
3. 贵州医科大学附属肿瘤医院 肿瘤科, 贵州 贵阳 550004;
4. 贵州医科大学附属肿瘤医院 头颈肿瘤科, 贵州 贵阳 550008
关键词:放射治疗 表皮生长因子受体 免疫疗法 西妥昔单抗 综述 
分类号:R739.91
出版年·卷·期(页码):2023·51·第十二期(1778-1783)
摘要:

目前放射治疗(RT)和化疗是头颈部鳞癌(HNSCC)的非手术头主要治疗方法。同步放化疗(CRT)可以在高危人群中降低疾病进展的风险。但是,寻找新的治疗方法仍然是必要的。在一些研究中,抗表皮生长因子受体(EGFR)抑制剂和免疫检查点抑制剂(ICIs)被用于与RT联合使用,以提高治疗效果。本文讨论了EGFR、PD-1/PD-L1受体抗体或其他ICIs与RT联合使用的证据,总结了将免疫治疗与RT相结合应用于局部晚期头颈部麟癌(LA-HNSCC)的临床试验,讨论了将免疫治疗与RT相结合作为HNSCC的降级治疗策略的潜力。通过文献检索发现联合使用RT和靶向治疗或免疫治疗,可以提高HNSCC的治疗效果,这对于开发针对癌症的个性化新型放射免疫治疗方法有极大的启发。

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