外周血NRR、LRR、MRR、NLR及MLR相关参数对慢性肾脏病进展的预测价值-现代医学

外周血NRR、LRR、MRR、NLR及MLR相关参数对慢性肾脏病进展的预测价值

单位：江苏省中医院/南京中医药大学附属医院检验科, 江苏南京 210029

关键词：慢性肾脏病中性粒细胞与红细胞比率淋巴细胞与红细胞比率单核细胞与红细胞比率中性粒细胞与淋巴细胞比率单核细胞与淋巴细胞比率

分类号：R692

出版年·卷·期（页码）：2023·51·第十一期（1578-1583）

摘要：

目的：探讨外周血中性粒细胞与红细胞比率(NRR)、淋巴细胞与红细胞比率(LRR)、单核细胞与红细胞比率(MRR)、中性粒细胞与淋巴细胞比率(NLR)及单核细胞与淋巴细胞比率(MLR)对不同分期慢性肾脏病的诊断价值。方法：收集2021年2月至2022年2月江苏省中医院肾内科收治入院的148例慢性肾脏病患者及50例健康体检者作为训练集，根据肾小球滤过率(eGFR)将慢性肾脏病分为3期，其中慢性肾脏病3期43例(30结果：慢性肾脏病患者外周血NRR、LRR、MRR、NLR及MLR显著高于正常对照组(P<0.05)。随着eGFR数值的降低，NRR、LRR、MRR、NLR及MLR数值均逐渐升高，差异具有统计学意义(P<0.05)，治疗前后NRR、LRR、MRR、NLR及MLR差异具有统计学意义(P<0.05)。ROC曲线结果表明，NRR、LRR、MRR、NLR、MLR及联合诊断对CKD具有较好的诊断价值。验证集数据表明，NRR、LRR、MRR、NLR及MLR联合检测CKD的灵敏度和特异度均满足要求。结论：NRR、LRR、MRR、NLR、MLR对不同分期慢性肾脏病进展诊断具有一定的应用价值，并且单独及联合检测对慢性肾脏病治疗效果监测均具有参考意义。

Objective: To explore the diagnostic value of peripheral blood neutrophil to red blood cell ratio(NRR), lymphocyte to red blood cell ratio(LRR), monocyte to red blood cell ratio(MRR), neutrophil to lymphocyte ratio(NLR) and monocyte to lymphocyte ratio(MLR) in different stages of chronic kidney disease(CKD). Methods: From February 2021 to February 2022, 148 patients with CKDand 50 healthy physical examiners(control group) admitted to the Department of Nephrology of Jiangsu Provincial Hospital of Chinese Medicine were collected as a training set. According to the estimated glomerular filtration rate(eGFR), CKD was divided into three stages, including 43 patients with CKD stage 3(30Results: The values of NRR, LRR, MRR, NLR and MLR of peripheral blood from patients with CKD were significantly higher than those of normal controls(P<0.05). In addition, as the values of eGFR decreased, the values of NRR, LRR, MRR, NLR, and MLR gradually increased, and the difference was statistically significant(P<0.05). The results also showed significant difference before and after treatment in the values of NRR, LRR, MRR, NLR, and MLR in patients with CKD(P<0.05). ROC curve analysis showed that NRR, LRR, MRR, NLR, MLR and combined diagnosis had good diagnostic value for CKD. At the same time, the validation set data showed that the sensitivity and specificity of combined NRR, LRR, MRR, NFR and MLR detection of CKD met the requirements. Conclusion: NRR, LRR, MRR, NLR, and MLR have certain application value in the diagnosis of CKD progression in different stages, and the single and combined detections of the above indicators have reference significance for monitoring the therapeutic effect of CKD.

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