睡眠障碍与卒中风险的因果关系：孟德尔随机化研究-现代医学

睡眠障碍与卒中风险的因果关系：孟德尔随机化研究

单位：1. 黑龙江中医药大学, 黑龙江哈尔滨 150040;
2. 黑龙江中医药大学附属第二医院, 黑龙江哈尔滨 150000

分类号：R743.3

出版年·卷·期（页码）：2023·51·第十一期（1559-1565）

摘要：

目的：通过两样本孟德尔随机化(MR)研究方法探究睡眠障碍(SD)与卒中发生之间的潜在因果关系。方法：分别从UK biobank、FinnGen数据库中获取SD和卒中的全基因组关联研究(GWAS)汇总数据，提取显著且独立(P＜5×10^-8；F＞10；r²=0.001；kb=10 000)的单核苷酸多态性(SNPs)用于MR分析；采用逆方差加权法(IVW)、加权中值法(WME)和MR-Egger三种方法评估因果关系，并进行各种互补敏感性分析以保证结果的稳固。结果：共筛选到14个SNPs作为工具变量，IVW显示SD与卒中间存在正向因果关系(OR=1.264, 95%CI 1.122~1.423，P＜0.05)，WME结果与之相似(OR=1.253, 95%CI 1.072~1.465，P＜0.05)，敏感性分析显示结果稳固无偏倚。结论：睡眠障碍与卒中发生存在正向因果关系。

Objective: To explore the potential causality between sleep disorder and stroke by two sample Mendelian randomization(MR). Methods: The summary data for sleep disorder and stroke were obtained from the genome-wide association study(GWAS) in UK biobank and FinnGen databases respectively. Significant and independent(P<5×10^-8;F>10;r²=0.001;kb=10 000) single-nucleotide polymorphisms(SNPs) were extracted for MR analysis. Inverse variance weighted(IVW), weighted median estimator(WME) and MR-Egger were usedto assess causality and various complementary sensitivity analyses were conducted to ensure robust results.Results: A total of 14 SNPs were screened as instrumental variables, and IVW showed a positive causal relationship between SD and stroke(OR=1.264, 95%CI 1.122-1.423, P<0.05), with similar results for WME(OR=1.253, 95%CI 1.072-1.465, P<0.05).Sensitivity analysis showed that the results were robust and unbiased. Conclusion: There is a positive causal relationship between sleep disorder and stroke.

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