目的：对膝骨关节炎（KOA）合并肌少症的危害、评估工具、影响因素、干预措施进行范围综述，为今后该领域的研究提供指导。方法：采用范围综述研究框架，计算机检索中国知网、万方、维普、中国生物医学文献数据库、EMbase、Web of Science、The Cochrane Library、PubMed、Springer Link数据库，检索时限为建库至2023年5月。根据纳入和排除标准确定相关文献，并对文献进行数据提取、收集、总结并报告研究结果。结果：共纳入16篇文献。结果显示，肌少症会增加KOA患者跌倒的风险、疼痛程度，加剧膝关节功能损害和疾病进展，影响生活质量。肌少症在KOA中的评估诊断工具较少，其主要影响因素包括社会人口学因素、躯体因素和疾病因素，干预方法可分为运动联合性干预和肌肉电刺激两种类型。结论：肌少症会严重影响KOA患者的生存质量，临床医护人员应注重肌少症在改善个体健康结局中的作用，规范评价指标和工具，并根据影响因素制定个性化的干预措施，以帮助患者改善肌少症。

[1] CROSS M, SMITH E, HOY D, et al.The global burden of hip and knee osteoarthritis:estimates from the global burden of disease 2010 study[J].Ann Rheum Dis, 2014, 73(7):1323-1330.
[2] 郑燕蓉, 林莉, 毛月.老年慢病共病人群中肌肉减少症患病情况研究[J].现代医学, 2022, 50(5):618-623.
[3] KIRK B, AL S A, DUQUE G.Osteosarcopenia:a case of geroscience[J].Aging Med (Milton), 2019, 2(3):147-156.
[4] COLQUHOUN H L, LEVAC D, O'BRIEN K K, et al.Scoping reviews:time for clarity in definition, methods, and reporting[J].J Clin Epidemiol, 2014, 67(12):1291-1294.
[5] IIJIMA H, AOYAMA T.Increased recurrent falls experience in older adults with coexisting of sarcopenia and knee osteoarthritis:a cross-sectional study[J].BMC Geriatr, 2021, 21(1):698-705.
[6] 罗宇.老年住院患者肌肉减少症与膝骨关节炎的相关性分析[D].重庆:重庆医科大学, 2021.
[7] ANDREWS J S, GOLD L S, NEVITT M, et al.Appendicular lean mass, grip strength, and the development of knee osteoarthritis and knee pain among older adults[J].ACR Open Rheumatology, 2021, 3(8):566-572.
[8] KIM M J, KANG B H, PARK S H, et al.Association of the western ontario and mcmaster universities osteoarthritis index (WOMAC) with muscle strength in community-dwelling elderly with knee osteoarthritis[J].Int J Environ Res Public Health, 2020, 17(7):2260-2270.
[9] REID K F, PRICE L L, HARVEY W F, et al.Muscle power is an independent determinant of pain and quality of life in knee osteoarthritis[J].Arthritis and Rheumatology, 2015, 67(12):3166-3173.
[10] 段玉梅.中老年膝骨性关节炎患者肌少症现状及其对生活质量的影响[D].遵义:遵义医科大学, 2021.
[11] KIM H T, KIM H J, AHN H Y, et al.An analysis of age-related loss of skeletal muscle mass and its significance on osteoarthritis in a Korean population[J].Korean J Intern Med, 2016, 31(3):585-593.
[12] 张强强.肌少因素对肝肾亏虚型KOA患者的影响及与膝关节X线影像相关性分析的研究[D].天津:天津中医药大学, 2022.
[13] VERONESE N, STEFANAC S, KOYANAGI A, et al.Lower limb muscle strength and muscle mass are associated with incident symptomatic knee osteoarthritis:a longitudinal cohort study[J].Front Endocrinol (Lausanne), 2021, 12:804560.
[14] ASLAN S G, GENÇ H.Sarcopenia in knee osteoarthritis:the association with clinical and sonographic findings, physical function, and nutrition[J].Ir J Med Sci, 2023, 192(3):1231-1239.
[15] LOVETT M, NEGM A, IOANNIDIS G, et al.Identifying patients with osteoarthritis at risk of sarcopenia using the SARC-F[J].Can Geriatr J, 2021, 24(1):1-7.
[16] SAFONOVA Y A, ZOTKIN E G.Sarcopenia in older patients with osteoarthritis of large joints[J].Rheumatology Science and Practice, 2019, 57(2):154-159.
[17] MITOMA T, MAKI J, OOBA H, et al.Protocol for a randomised, placebo-controlled, double-blinded clinical trial on the effect of oestrogen replacement on physical performance to muscle resistance exercise for older women with osteoarthritis of knee joint:the EPOK trial[J].BMC geriatrics, 2023, 23(1):104-116.
[18] LIAO C D, LIAO Y H, LIOU T H, et al.Effects of protein-rich nutritional composition supplementation on sarcopenia indices and physical activity during resistance exercise training in older women with knee osteoarthritis[J].Nutrients, 2021, 13(8):2487-2507.
[19] PETERSEN S G, BEYER N, HANSEN M, et al.Nonsteroidal anti-inflammatory drug or glucosamine reduced pain and improved muscle strength with resistance training in a randomized controlled trial of knee osteoarthritis patients[J].Arch Phys Med Rehabil, 2011, 92(8):1185-1193.
[20] DE OLIVEIRA M M, POMPEO K D, BARONI B M, et al.Effects of neuromuscular electrical stimulation and low-level laser therapy on neuromuscular parameters and health status in elderly women with knee osteoarthritis:a randomized trial[J].J Rehabil Med, 2016, 48(3):293-299.
[21] XU J, SHE G, GUI T, et al.Knee muscle atrophy is a risk factor for development of knee osteoarthritis in a rat model[J].J Orthop Translat, 2020, 22:67-72.
[22] 刘杰, 盛逸澜, 余波.老年原发性肌少症的诊断和评估新进展[J].实用老年医学, 2023, 37(1):1-4.
[23] 王欢, 孙贺, 张耀南, 等.中国40岁以上人群原发性膝骨关节炎各间室患病状况调查[J].中华骨与关节外科杂志, 2019, 12(7):528-532.
[24] SAMSON M M, MEEUWSEN I B, CROWE A, et al.Relationships between physical performance measures, age, height and body weight in healthy adults[J].Age Ageing, 2000, 29(3):235-242.
[25] BERENBAUM F.Diabetes-induced osteoarthritis:from a new paradigm to a new phenotype[J].Ann Rheum Dis, 2011, 70(8):1354-1356.
[26] VERONESE N, COOPER C, REGINSTER J Y, et al.Type 2 diabetes mellitus and osteoarthritis[J].Semin Arthritis Rheum, 2019, 49(1):9-19.
[27] 王建华, 冯玫, 乔爱春, 等.脑梗死合并肌少症患者的临床特征及相关影响因素研究[J].中华全科医师杂志, 2020, 19(9):824-828.
[28] CASTILHO DE ALMEIDA A, AILY J, PEDROSO M, et al.Middle-aged adults with knee osteoarthritis present worse sarcopenia parameters, symptoms and functional performance[J].Osteoarthritis and Cartilage, 2020, 28:S399-S400.
[29] SUH D H, HAN K D, HONG J Y, et al.Body composition is more closely related to the development of knee osteoarthritis in women than men:a cross-sectional study using the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-1, 2)[J].Osteoarthritis and Cartilage, 2016, 24(4):605-611. 欢迎订阅欢迎投稿