Objective: To investigate the safety and efficacy of neoadjuvant immunotherapy combined with chemotherapy for locally advanced non-small cell lung cancer. Methods: 36 patients with locally advanced non-small cell lung cancer who received neoadjuvant immunotherapy combined with chemotherapy in the Department of Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College from December 1,2020 to December 1,2022 were retrospectively included in this study. Results: The objective response rate(ORR) and disease control rate(DCR) were 86.1% and 91.7%, respectively. Among them, 5 patients(13.8%) had complete response(CR), 26 patients(72.2%) had partial response(PR), 2 patients(5.6%) had stable disease(SD), and 3 patients(8.3%) had progressive disease(PD). 30 patients were R0 resection, and the surgical resection rate was 83.3%. Adverse reactions in the whole group were mainly grade 1 and 2, and the most common adverse reactions were alopecia, rash, elevated transaminases, hypothyroidism, leukopenia, neutropenia, thrombocytopenia and gastrointestinal reactions such as nausea, vomiting, diarrhea, and constipation. Grade 3 adverse reactions occurred in only 3 patients, and no grade 4 adverse reactions occurred. Conclusion: Neoadjuvant immunotherapy combined with chemotherapy has good safety and efficacy in locally advanced non-small cell lung cancer, which is worthy of further exploration. |
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