2型糖尿病患者红细胞参数与糖化血红蛋白水平的相关性研究-现代医学

2型糖尿病患者红细胞参数与糖化血红蛋白水平的相关性研究

单位：1. 淮北市中心血站, 安徽淮北 235000;
2. 淮北市人民医院输血科, 安徽淮北 235000

分类号：R459.7

出版年·卷·期（页码）：2023·51·第十期（1453-1458）

摘要：

目的：探讨2型糖尿病（T2DM）患者红细胞参数与糖化血红蛋白水平的关系。方法：本研究纳入T2DM患者346例，收集临床资料和实验室检查指标，根据糖化血红蛋白水平分为未达标组与达标组，并比较两组患者的临床和实验室检查资料。结果：未达标组T2DM患者糖化血红蛋白水平与达标组相比，外周血红细胞计数显著升高（P=0.024），平均红细胞体积显著减少（P=0.002）。相关分析表明，在T2DM患者中，外周血红细胞计数与糖化血红蛋白水平呈正相关（r=0.141，P=0.009），平均红细胞体积与糖化血红蛋白水平呈负相关（r=-0.283，P<0.001）。多元线性回归分析表明，糖化血红蛋白水平是T2DM患者外周血红细胞计数升高（β=0.069，P=0.015）和平均红细胞体积减小（β=-0.134，P=0.031）的独立危险因素。结论：T2DM患者的外周血红细胞计数和平均红细胞体积与糖化血红蛋白水平相关，血常规检查中的红细胞参数值可提示血糖长期控制情况。

Objective: To reveal the association between erythrocyte parameters and glycosylated hemoglobin in patients with type 2 diabetes mellitus(T2DM). Methods: A total of 346 T2DM patients were included in this study. The T2DM patients were divided into qualified glycosylated hemoglobin group and non-qualified glycosylated hemoglobin group according to the glycosylated hemoglobin levels, and the clinical and laboratory examination data were compared between the two groups. Results: Compared with the qualified glycosylated hemoglobin group, peripheral red blood cell count was significantly increased(P=0.024), and mean corpuscular volume was significantly decreased(P=0.002), in non-qualified glycosylated hemoglobin group. Correlation analysis showed that red blood cell count was positively correlated with glycosylated hemoglobin(r=0.141, P=0.009), and mean corpuscular volume was negatively correlated with glycosylated hemoglobin in T2DM patients(r=-0.283, P<0.001). Multiple linear regression analysis showed that glycosylated hemoglobin level was an independent risk factor for increased peripheral red blood cell count(β=0.069, P=0.015) and decreased mean corpuscular volume(β=-0.134, P=0.031) in patients with T2DM. Conclusions: Peripheral red blood cell count and mean corpuscular volume are correlated with glycosylated hemoglobin level in T2DM patients, and they can reflect the long-term glycemic control to a certain extent in T2DM patients.

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