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Willis环完整性与脑白质病变程度相关性的Meta分析
作者:郝慧霏1  陈志刚2  任甫卿1  韩刚3 
单位:1. 北京中医药大学, 北京 100029;
2. 北京中医药大学东方医院 脑病一科, 北京 100078;
3. 北京中医药大学东方医院 脑病二科, 北京 100078
关键词:威利斯环 脑白质病变 相关性 严重程度 Meta分析 
分类号:R743.9
出版年·卷·期(页码):2023·51·第十期(1403-1410)
摘要:

目的:探讨威利斯环(Willis环)完整性与脑白质病变(WML)程度的相关性。方法:检索自建库起至2022年10月中国知网(CNKI)、万方、中国生物医学文献数据库(CBM)、PubMed、Embase、Web of Science数据库中有关Willis环与WML相关性的中英文文献,RevMan 5.3和Stata17.0软件用于Meta分析。结果:共纳入11篇文献,包含1 145名研究对象。与Willis环完整组相比,Willis环不完整组严重WML发生率更高(OR=2.07,95%CI 1.22~3.50,P<0.05);从WML评分来看,Willis环不完整组WML评分更高(SMD=1.29,95%CI 0.99~1.59,P<0.05),且对于皮质下深部白质病变(DWML)(SMD=1.26,95%CI 0.88~1.64,P<0.05),脑室旁白质病变(PWML)(SMD=1.16,95%CI 0.69~1.63,P<0.05)差异均具有统计学意义(均P<0.05);在报告WML体积的研究中,Willis环变异组的WML病变体积也更大(P=0.0405)。结论:Willis环不完整与严重WML相关。

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