[1] OLOFSSON B,JELTSCH M,ERIKSSON U,et al.Current biology of VEGF-B and VEGF-C[J].Curr Opin Biotechnol,1999,10(6):528-535.
[2] LEUNG D W,CACHIANES G,KUANG W J,et al.Vascular endothelial growth factor is a secreted angiogenic mitogen[J].Science,1989,246(4935):1306-1309.
[3] BETSHOLTZ C,JOHNSSON A,HELDIN C H,et al.cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines[J].Nature,1986,320(6064):695-699.
[4] MAMER S B,WITTENKELLER A,IMOUKHUEDE P I.VEGF-A splice variants bind VEGFRs with differential affinities[J].Sci Rep,2020,10(1):14413.
[5] 米日喀米力·玉苏甫.VEGFR-2在鼻咽癌中的表达与PI3K/AKT信号通路相关性的初步研究[D].长沙:中南大学,2013.
[6] 冉俊.PI3K/AKT/mTOR信号通路与鼻咽癌CNE1-LMP1细胞原发吉非替尼耐药关系的研究[D].武汉:华中科技大学,2012.
[7] LI X,PADHAN N,SJÖSTRÖM E O,et al.VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread[J].Nat Commun,2016,7:11017.
[8] CHEN X L,NAM J O,JEAN C,et al.VEGF-induced vascular permeability is mediated by FAK[J].Dev Cell,2012,22(1):146-157.
[9] HE L,FENG A,GUO H,et al.LRG1 mediated by ATF3 promotes growth and angiogenesis of gastric cancer by regulating the SRC/STAT3/VEGFA pathway[J].Gastric Cancer,2022,25(3):527-541.
[10] GRAUPERA M,GUILLERMET-GUIBERT J,FOUKAS L C,et al.Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration[J].Nature,2008,453(7195):662-666.
[11] TIAN J,CHENG L,KONG E,et al.Linc00958/miR-185-5p/RSF-1 modulates cisplatin resistance and angiogenesis through AKT1/GSK3β/VEGFA pathway in cervical cancer[J].Reprod Biol Endocrinol,2022,20(1):132.
[12] WANG Z,JIANG L,WANG J,et al.Morphine promotes angiogenesis by activating PI3K/Akt/HIF-1αpathway and upregulating VEGF in hepatocellular carcinoma[J].J Gastrointest Oncol,2021,12(4):1761-1772.
[13] SADREMOMTAZ A,MANSOURI K,ALEMZADEH G,et al.Dual blockade of VEGFR1 and VEGFR2 by a novel peptide abrogates VEGF-driven angiogenesis,tumor growth,and metastasis through PI3K/AKT and MAPK/ERK1/2 pathway[J].Biochim Biophys Acta Gen Subj,2018,1862(12):2688-2700.
[14] PENG C,CHEN H,LI Y,et al.LRIG3 suppresses angiogenesis by regulating the PI3K/AKT/VEGFA signaling pathway in glioma[J].Front Oncol,2021,11:621154.
[15] LUO J,YAO J F,DENG X F,et al.14,15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin αvβ3 and activating FAK/PI3K/AKT signaling[J].J Exp Clin Cancer Res,2018,37(1):23.
[16] CARMELIET P,LAMPUGNANI M G,MOONS L,et al.Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis[J].Cell,1999,98(2):147-157.
[17] HOXHAJ G,MANNING B D.The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism[J].Nat Rev Cancer,2020,20(2):74-88.
[18] FUKUSHIMA Y,NISHIYAMA K,KATAOKA H,et al.RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells[J].EMBO J,2020,39(12):e102930.
[19] MCMULLEN M E,BRYANT P W,GLEMBOTSKI C C,et al.Activation of p38 has opposing effects on the proliferation and migration of endothelial cells[J].J Biol Chem,2005,280(22):20995-21003.
[20] CHEN W,SHEN Z,CAI S,et al.FGF21 promotes wound healing of rat brain microvascular endothelial cells through facilitating TNF-α-mediated VEGFA and ERK1/2 signaling pathway[J].Adv Clin Exp Med,2021,30(7):711-772.
[21] ZHAO S,GUAN X,HOU R,et al.Vitexin attenuates epithelial ovarian cancer cell viability and motility in vitro and carcinogenesis in vivo via p38 and ERK1/2 pathways related VEGFA[J].Ann Transl Med,2020,8(18):1139.
[22] FANG L,LI Y,WANG S,et al.TGF-β1 induces VEGF expression in human granulosa-lutein cells:a potential mechanism for the pathogenesis of ovarian hyperstimulation syndrome[J].Exp Mol Med,2020,52(3):450-460.
[23] CARMELIET P,JAIN R K.Angiogenesis in cancer and other diseases[J].Nature,2000,407(6801):249-257.
[24] CARMELIET P.Angiogenesis in life,disease and medicine[J].Nature,2005,438(7070):932-936.
[25] WANG L A,YANG B,TANG T,et al.Correlation of APE1 with VEGFA and CD163(+) macrophage infiltration in bladder cancer and their prognostic significance[J].Oncol Lett,2020,20(3):2881-2887.
[26] SHEN X C,ZHAN S H,XU S T,et al.Prognostic and clinicopathologic significance of PAQR3 and VEGF-A expression in pulmonary adenocarcinoma[J].Int J Clin Exp Pathol,2020,13(7):1676-1681.
[27] CHENG S,ZHANG X,XU Y,et al.Krüppel-like factor 8 regulates VEGFA expression and angiogenesis in hepatocellular carcinoma[J].Sci Rep,2018,8(1):17415.
[28] PǍNUŞ A,SIMIONESCU C E,DRǍGOESCU P O,et al.VEGF Immunoexpression in Prostate Adenocarcinoma[J].Curr Health Sci J,2021,47(1):89-95.
[29] LI G,LI X,YUAN C,et al.Long non-coding RNA JPX contributes to tumorigenesis by regulating miR-5195-3p/VEGFA in non-small cell lung cancer[J].Cancer Manag Res,2021,13:1477-1489.
[30] LI X,HU Z,SHI H,et al.Inhibition of VEGFA increases the sensitivity of ovarian cancer cells to chemotherapy by suppressing VEGFA-mediated autophagy[J].Onco Targets Ther,2020,13:8161-8171.
[31] GUAN J H,CAO Z Y,GUAN B,et al.Effect of Babao Dan on angiogenesis of gastric cancer in vitro by regulating VEGFA/VEGFR2 signaling pathway[J].Transl Cancer Res,2021,10(2):953-965.
[32] CHEN X,XU X,PAN B,et al.miR-150-5p suppresses tumor progression by targeting VEGFA in colorectal cancer[J].Aging(Albany NY),2018,10(11):3421-3437.
[33] CHEN J Q,TAO Y P,HONG Y G,et al.M(6)A-mediated up-regulation of LncRNA LIFR-AS1 enhances the progression of pancreatic cancer via miRNA-150-5p/VEGFA/Akt signaling[J].Cell Cycle,2021,20(23):2507-2518.
[34] HUNTER S,NAULT B,UGWUAGBO K C,et al.Mir526b and mir655 promote tumour associated angiogenesis and lymphangiogenesis in breast cancer[J].Cancers(Basel),2019,11(7):938.
[35] HANAHAN D,FOLKMAN J.Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis[J].Cell,1996,86(3):353-364.
[36] XUE N,FU X,ZHU Y,et al.Moxibustion enhances chemotherapy of breast cancer by affecting tumor microenvironment[J].Cancer Manag Res,2020,12:8015-8022.
[37] ZHANG H,WANG Y,HE Z.Glycine-histidine-lysine(GHK) alleviates neuronal apoptosis due to intracerebral hemorrhage via the miR-339-5p/VEGFA pathway[J].Front Neurosci,2018,12:644.
[38] WEI H,CAO C,WEI X,et al.Circular RNA circVEGFC accelerates high glucose-induced vascular endothelial cells apoptosis through miR-338-3p/HIF-1α/VEGFA axis[J].Aging(Albany NY),2020,12(14):14365-14375.
[39] ZHAN S,WANG C,YIN F.MicroRNA-29c inhibits proliferation and promotes apoptosis in non-small cell lung cancer cells by targeting VEGFA[J].Mol Med Rep,2018,17(5):6705-6710.
[40] QIN C,ZHA W,FAN R,et al.MicroRNA-302a inhibits cell proliferation and invasion,and induces cell apoptosis in hepatocellular carcinoma by directly targeting VEGFA[J].Mol Med Rep,2017,16(5):6360-6367.
[41] XIE Y,LIU X,HU T,et al.miR-302e suppresses glioma progression by targeting VEGFA[J].Cancer Manag Res,2020,12:10965-10974.
[42] WANG R,MA Q,JI L,et al.miR-622 suppresses tumor formation by directly targeting VEGFA in papillary thyroid carcinoma[J].Onco Targets Ther,2018,11:1501-1509.
[43] CHEN C H,HSU F T,CHEN W L,et al.Induction of apoptosis,inhibition of MCL-1,and VEGF-A expression are associated with the anti-cancer efficacy of magnolol combined with regorafenib in hepatocellular carcinoma[J].Cancers(Basel),2021,13(9):2066.
[44] CHEN Q,WANG D,LI Y,et al.LINC00628 suppresses migration and invasion of hepatocellular carcinoma by its conserved region interacting with the promoter of VEGFA[J].J Cell Physiol,2019,234(9):15751-15762.
[45] WANG H,YANG Q,LI J,et al.MicroRNA-15a-5p inhibits endometrial carcinoma proliferation,invasion and migration via downregulation of VEGFA and inhibition of the Wnt/β-catenin signaling pathway[J].Oncol Lett,2021,21(4):310.
[46] LAI S W,CHEN M Y,BAMODU O A,et al.Exosomal lncRNA PVT1/VEGFA axis promotes colon cancer metastasis and stemness by downregulation of tumor suppressor miR-152-3p[J].Oxid Med Cell Longev,2021:9959807.
[47] WANG R,SUN S,WANG Z,et al.MCPIP1 promotes cell proliferation,migration and angiogenesis of glioma via VEGFA-mediated ERK pathway[J].Exp Cell Res,2022,418(1):113267.
[48] GUO X,CHEN M,CAO L,et al.Cancer-associated fibroblasts promote migration and invasion of non-small cell lung cancer cells via miR-101-3p mediated VEGFA secretion and AKT/eNOS pathway[J].Front Cell Dev Biol,2021,9:764151.
[49] YAN X,HUI Y,HUA Y,et al.EG-VEGF silencing inhibits cell proliferation and promotes cell apoptosis in pancreatic carcinoma via PI3K/AKT/mTOR signaling pathway[J].Biomed Pharmacother,2019,109:762-769.
[50] WU W,ZAAL E A,BERKERS C R,et al.CTGF/VEGFA-activated fibroblasts promote tumor migration through micro-environmental modulation[J].Mol Cell Proteomics,2018,17(8):1502-1514.
[51] TANAKA M,SIEMANN D W.Gas6/Axl signaling pathway in the tumor immune microenvironment[J].Cancers(Basel),2020,12(7):1850.
[52] WU G,MA Z,CHENG Y,et al.Targeting Gas6/TAM in cancer cells and tumor microenvironment[J].Mol Cancer,2018,17(1):20.
[53] TANAKA M,SIEMANN D W.Therapeutic targeting of the Gas6/Axl signaling pathway in cancer[J].Int J Mol Sci,2021,22(18):9953.
[54] TOBONI M D,LOMONOSOVA E,BRUCE S F,et al.Inhibition of AXL and VEGF-A has improved therapeutic efficacy in uterine serous cancer[J].Cancers(Basel),2021,13(23):5877.
[55] JIN L,HAN C,ZHAI T,et al.Circ_0030998 promotes tumor proliferation and angiogenesis by sponging miR-567 to regulate VEGFA in colorectal cancer[J].Cell Death Discov,2021,7(1):160.
[56] LIU X,HE H,ZHANG F,et al.m6A methylated EphA2 and VEGFA through IGF2BP2/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K/AKT and ERK1/2 signaling[J].Cell Death Dis,2022,13(5):483.
[57] PENG T,LI Z,LI D,et al.MACC1 promotes angiogenesis in cholangiocarcinoma by upregulating VEGFA[J].Onco Targets Ther,2019,12:1893-1903.
[58] WANG X,QIN H.TFF3 promotes pituitary tumor cell migration and angiogenesis via VEGFA[J].Acta Neurobiol Exp(Wars),2022,82(2):237-243.
[59] CHEN L,XIE X,WANG T,et al.ARL13B promotes angiogenesis and glioma growth by activating VEGFA-VEGFR2 signaling[J].Neuro Oncol,2022,25(5):871-885.
[60] MOUSA H,YUAN M,ZHANG X,et al.MicroRNA-4316 inhibits gastric cancer proliferation and migration via directly targeting VEGF-A[J].Cancer Cell Int,2020,20:62.
[61] ZHANG L,CAO H,GU G,et al.Exosomal miR-199a-5p inhibits tumorigenesis and angiogenesis by targeting VEGFA in osteosarcoma[J].Front Oncol,2022,12:884559.
[62] ZHANG L,LV Z,XU J,et al.MicroRNA-134 inhibits osteosarcoma angiogenesis and proliferation by targeting the VEGFA/VEGFR1 pathway[J].FEBS J,2018,285(7):1359-1371.
[63] RAO X,WAN L,JIE Z,et al.Upregulated miR-27a-3p indicates a poor prognosis in pancreatic carcinoma patients and promotes the angiogenesis and migration by epigenetic silencing of GATA6 and activating VEGFA/VEGFR2 signaling pathway[J].Onco Targets Ther,2019,12:11241-11254.
[64] SHI C,YANG Q,PAN S,et al.LncRNA OIP5-AS1 promotes cell proliferation and migration and induces angiogenesis via regulating miR-3163/VEGFA in hepatocellular carcinoma[J].Cancer Biol Ther,2020,21(7):604-614.
[65] VIMALRAJ S,SUBRAMANIAN R,DHANASEKARAN A.LncRNA MALAT1 promotes tumor angiogenesis by regulating microRNA-150-5p/VEGFA signaling in osteosarcoma:in-vitro and in-vivo analyses[J].Front Oncol,2021,11:742789.
[66] ZHANG D,JIANG H,YE J,et al.A novel lncRNA,RPL34-AS1,promotes proliferation and angiogenesis in glioma by regulating VEGFA[J].J Cancer,2021,12(20):6189-6197.
[67] YANG H,YANG W,DAI W,et al.LINC00667 promotes the proliferation,migration,and pathological angiogenesis in non-small cell lung cancer through stabilizing VEGFA by EIF4A3[J].Cell Biol Int,2020,44(8):1671-1680. |
