目的：探究腰4/5节段不同类型的终板缺损与腰椎间盘退变的关系。方法:收集整理2019年3月至2022年3月因慢性下腰痛就诊的患者临床资料，共280例。根据核磁共振表现将退变程度分轻度腰椎间盘退变组(84例)和重度腰椎间盘退变组(196例)。观察性别、年龄、体质量指数(BMI)、吸烟史、腰4/5节段终板缺损类型、Modic改变等临床资料。对上述临床资料进行单因素分析，对于有统计学意义的参数进行Logistic回归分析。结果：本研究共纳入280例患者，其中男153例，女127例；年龄25~82岁，平均(45.9±8.0)岁；影像学统计结果显示终板缺损的发生率为54.6%，单因素分析结果显示两组在年龄、BMI、终板缺损类型、Modic改变方面差异具有统计学意义(P<0.05)。Logistic回归分析显示年龄、终板缺损类型是腰椎间盘退变的危险因素，边缘(Corner)型、侵蚀(Erosive)型终板可能诱发腰椎间盘退变(P<0.05)。结论： 终板缺损是腰椎间盘退变的危险因素，Corner型、Erosive型缺损更容易诱发严重腰椎间盘退行性改变的发生，因此对于终板早期损伤的患者应及时健康宣教。

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