目的：探讨年龄校正查尔森合并症指数(aCCI)及使用AN69-ST或AN69-oXiris膜材对行连续肾脏替代治疗(CRRT)的脓毒症合并急性肾损伤(SA-AKI)患者预后的影响。方法:回顾性连续收集2019年1月1日至2021年12月1日新疆医科大学第一附属医院收治的接受CRRT的SA-AKI患者。收集临床资料行单因素Logistic回归分析，用受试者工作特征(ROC)曲线对比有统计意义因素的AUC值及其他性能参数。以最大约登指数对应aCCI的最佳截断值将患者分为高aCCI组及低aCCI组，将两组分别进行卡方检验比较使用AN69-ST或AN69-oXiris膜材的28 d死亡率，采用惠曼特尼U检验分析组间次要结局的差异。结果：66例患者入院28 d内死亡31例。单因素分析显示，aCCI、英国国家早期预警评分(NEWS)、脓毒症相关器官衰竭评估(SOFA)、急性生理学和慢性健康评估Ⅱ(APACHE Ⅱ)评分、快速序贯器官衰竭评分(qSOFA)是SA-AKI患者入院28 d内死亡的危险因素(均OR>1，均P<0.05)；aCCI 10年死亡率预测值(aCCI live-10 years)、格拉斯哥昏迷评分(GCS)是SA-AKI患者入院起28 d内死亡的保护因素(均OR<1，均P<0.05)；而使用AN69-ST或AN69-oXiris膜材治疗对SA-AKI患者28 d内死亡无显著影响(P>0.05)。高aCCI组及低aCCI组分别为20、46例，在低aCCI组患者人群中，使用AN69-oXiris膜材治疗的患者，28 d死亡率更低(P<0.05)。高aCCI组及低aCCI组两组间患者总住院时间比较，低aCCI组较高aCCI组住院时间长，差异有统计学意义(P<0.05)。结论：(1) aCCI、qSOFA、NEWS、GCS、SOFA、APACHE Ⅱ评分对SA-AKI患者短期预后有显著影响。(2) SA-AKI患者在aCCI较低时，选用AN69-oXiris膜材与AN69-ST膜材相比，可降低患者28 d死亡率。

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