Objective: To analyze the value of combined serum C-reactive protein/albumin(CRP/ALB) and procalcitonin(PCT)/ALB assays in the assessment of disease and prognosis in patients with chronic kidney disease(CKD). Methods: 154 patients with CKD diagnosed and treated at the Handan 285 Hospital from February 2019 to May 2021 were retrospectively selected as study group, and 32 healthy subjects who underwent physical examination during the same period were selected as control group. The serum levels of CRP, ALB and PCT were determined and the ratios of CRP/ALB and PCT/ALB were calculated. The Pearson correlation test was used to analyze the relationship between CRP, ALB, PCT and the condition of patients with CKD and the multi-factor logistic regression analysis was used to analyze the factors influencing the prognosis of CKD. The prognostic value of the combined serum CRP/ALB and PCT/ALB tests was analyzed by the receiver operating characteristic(ROC) curve. Results: Compared with the control group, serum CRP, PCT levels and CRP/ALB, PCT/ALB were significantly higher and ALB levels were significantly lower in the study group(P<0.01). CRP, PCT, CRP/ALB and PCT/ALB levels gradually increased and ALB levels gradually decreased with the aggravation of the disease(P<0.05). CRP, PCT, CRP/ALB and PCT/ALB were significantly and negatively correlated with glomerular filtration rate, and ALB was significantly and positively correlated with glomerular filtration rate(P<0.05). Multifactorial logistic regression analysis showed that CRP, PCT, CRP/ALB, and PCT/ALB were independent risk factors for poor prognosis in patients with CKD(P<0.05), and ALB was an independent protective factor(P<0.05). The area under the curve(AUC) of the combination of CRP/ALB and PCT/ALB for predicting prognosis in patients with CKD was 0.889. Conclusion: Changes in serum CRP/ALB and PCT/ALB are of great reference value for understanding the degree of disease and prognosis assessment of patients CKD. |
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