Objective: To study the impact of different courses of neoadjuvant chemotherapy(NACT) on the short-term and long-term efficacy of advanced epithelial ovarian tumor. Methods: A retrospective analysis was conducted of 42 patients with advanced epithelial ovarian tumor who received NACT followed by intermittent tumor ablation(NACT-IDS) in our department from January 2015 to December 2018.According to the number of courses of NACT, they were divided into 4 groups: G1 group for 2 cycles, G2 group for 3 cycles, G3 group for 4 cycles, and G4 group for ≥5 cycles. The short-term and long-term therapeutic effects of patients in each group were observed. The short-term efficacy included changes of serum tumor marker CA125 levels before and after NACT, ratio of R0 without gross residual tumor, and pathological remission; long term efficacy indicators include progression-free survival(PFS) and overall survival(OS). Results: After NACT, the level of tumor marker CA125 in former three groups(G1, G2, G3) decreased by more than 90%, and there was no significant difference among these groups(P>0.05); The tumor markers in G4 group decreased by<80%, which was statistically different from the former three groups(P<0.05). The R0 ratio and pathological remission rate in G4 group were significantly lower than those in the former three groups(P<0.05); There was no significant difference among the former three groups(P>0.05). PFS and OS in G4 group were lower than those in the former three groups(P<0.05); There was no significant statistical difference between PFS and OS in the former three groups(P>0.05). Conclusion: By analyzing the impact of different NACT courses on the short-term and long-term outcomes of patients with advanced epithelial ovarian tumor, it is helpful to guide the clinical selection of appropriate surgical opportunities, improve the prognosis of patients, and avoid the negative impact of excessive neoadjuvant chemotherapy courses on the prognosis of patients. |
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