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糖基化在膀胱癌中作用的研究进展
作者:田浪  陆胜  赵伟  雷旭  何浩  尹娜  王彦 
单位:遵义医科大学第三附属医院(遵义市第一人民医院) 泌尿外科, 贵州 遵义 563000
关键词:糖基化 膀胱癌 聚糖 生物标志物 综述 
分类号:R737.14
出版年·卷·期(页码):2023·51·第二期(235-241)
摘要:

膀胱癌是发病率和死亡率最高的泌尿生殖系统恶性肿瘤之一。早期诊断和个体化治疗是膀胱癌治疗成功的关键。由于术后复发率高,晚期预后差,迫切需要寻找合适的治疗靶点和生物标记物。蛋白质糖基化的程度和碳水化合物结构的异常变化与肿瘤发生的程度有关,据报道它们在调节肿瘤侵袭、代谢和免疫方面发挥关键作用。本文旨在综述糖基化在膀胱癌中的重要生物学作用、相关标志物以及可能治疗靶点,为膀胱癌的个体化、综合性治疗提供新的策略。

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