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干燥综合征与抑郁症:两样本孟德尔随机化研究
作者:赵猛1  卫斐然2 
单位:1. 东南大学 公共卫生学院, 江苏 南京 210009;
2. 东南大学附属中大医院 风湿免疫科, 江苏 南京 210009
关键词:干燥综合征 抑郁症 孟德尔随机化 因果关联 
分类号:R593.2
出版年·卷·期(页码):2022·50·第十二期(1584-1588)
摘要:

目的:探讨干燥综合征(SS)与抑郁症之间的因果关联。方法:基于全基因组关联研究(GWAS)的汇总数据,选择与SS密切相关的遗传位点作为工具变量(IV)。采用逆方差加权法(IVW)、MR-Egger回归和加权中位数法(WM)的两样本孟德尔随机化(MR)方法进行分析,以评价SS与抑郁症之间的因果关联。结果:IVW、MR-Egger回归和WM计算得到的比值比(OR)和95%置信区间(CI)分别为1.002和0.995~1.010、1.010和0.950~1.072、1.001和0.950~1.011,所得结果基本一致。然而,各方法均显示SS与抑郁症之间的关联无统计学意义(P>0.05)。结论:尚未观察到SS与抑郁症之间的因果关联。

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