甲状腺功能亢进患者的焦虑、抑郁情绪及相关因素分析-现代医学

甲状腺功能亢进患者的焦虑、抑郁情绪及相关因素分析

单位：东南大学附属中大医院内分泌科, 江苏南京 210009

分类号：R581.1

出版年·卷·期（页码）：2022·50·第十二期（1507-1511）

摘要：

目的：探讨甲状腺功能亢进(甲亢)患者的情绪状况特点，分析甲状腺激素、抗体水平、病程及年龄等与情绪损伤的相关性。方法：选取38例甲亢患者(甲亢组)及38例年龄、性别相匹配的健康志愿者(对照组)作为本次研究对象，所有受试者接受甲状腺功能检测及汉密尔顿焦虑量表(HAMA)、汉密尔顿17抑郁量表(HAMD-17)评估。比较两组的焦虑和抑郁水平，Pearson相关分析探究焦虑抑郁水平与相关临床指标的相关性。结果：与对照组相比，甲亢组HAMA、HAMD-17评分显著升高(P<0.05)，甲亢患者HAMD-17评分与体质指数呈负相关，且HAMA评分与受教育年限及血清促甲状腺激素(TSH)水平呈负相关，与发病时间呈正相关(均P<0.05)。结论：甲亢患者存在焦虑及抑郁等情绪障碍，其严重程度与受教育程度、TSH水平及病程相关。

Objective: To investigate the features of the emotional status of hyperthyroid patients and analyze the relationship between levels of thyroid hormone, thyroid antibody, disease duration, age and the emotion impairments. Methods: 38 hyperthyroid patients(hyperthyroidism group) and 38 age-and gender-matched healthy volunteers(control group) were included in the study. All participant received neuropsychological assessment of mood including Hamilton Anxiety Scale(HAMA) and Hamilton Depression Rating Scale-17(HAMD-17). Compared the levels of anxiety and depression between the two groups, and Pearson correlation analysis was used to explore the correlation between anxiety and depression levels and related clinical indicators. Results: Compared with the control group, the HAMA and HAMD scores in the hyperthyroidism group were significantly increased(P<0.05). The HAMD score was negatively correlated with body mass index in patients with hyperthyroidism, and the HAMA score was negatively correlated with years of education and serum thyroid-stimulating hormone(TSH) level, and was positively correlated with disease duration(all P<0.05). Conclusion: Patients with hyperthyroidism have mood impairments such as anxiety and depression, and the severity is related to education level, TSH level and duration of disease.

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