晚期肺癌患者营养不良风险与生活质量的相关性及影响因素分析-现代医学

晚期肺癌患者营养不良风险与生活质量的相关性及影响因素分析

单位：1. 重庆医科大学附属巴南医院胸心外科, 重庆 401320;
2. 重庆医科大学附属巴南医院运营管理办公室, 重庆 401320;
3. 重庆医科大学附属巴南医院营养科, 重庆 401320

分类号：R734.2;R459.3

出版年·卷·期（页码）：2022·50·第十二期（1495-1499）

摘要：

目的：调查晚期肺癌患者营养不良风险、生活质量现状，探讨二者之间的相关性以及影响生活质量的因素。方法：筛选2020年1月至2022年1月我院住院的晚期肺癌患者，采用营养风险筛查2002(NRS 2002)、肺癌生活质量评定量表(FACT-L)评估患者的营养风险及生活质量；比较不同营养风险患者的体质指数(BMI)、血液学指标(包括TP、ALB、Hb)及生活质量等；分析营养不良风险与生活质量之间的相关性及生活质量的影响因素。结果：518例患者中307例有营养不良风险，占59.3%。有营养不良风险患者营养相关指标BMI及TP、ALB、Hb水平均显著低于无营养不良风险患者(均P＜0.05)。无营养不良风险患者FACT-L总分为(88.63±9.23)分，明显高于有营养不良风险患者的(82.74±9.91)分(P＜0.05)。相关分析结果显示，FACT-L评分与BMI、ALB水平呈正相关，与NRS 2002评分呈负相关。回归分析结果显示，NRS 2002评分是FACT-L总分的危险影响因素(P＜0.05)。结论：晚期肺癌患者中存在营养不良风险的比例较高，其营养相关指标显著低于无营养不良风险者；患者营养相关指标越高，营养不良风险越低，总体生活质量越高；有营养不良风险是影响患者生活质量的危险因素。临床上对有营养不良风险的肺癌患者应尽早给予营养支持，采取积极干预措施，以改善预后，提高患者生活质量。

Objective: To investigate the risk of malnutrition and quality of life in patients with advanced lung cancer, and to explore the correlation between the two and analyze the factors affecting the quality of life. Methods: The patients with advanced lung cancer hospitalized in our hospital from January 2020 to January 2022 were screened, and the nutritional risk and quality of life of the patients were assessed by using the nutrition risk screening scale 2002(NRS 2002) and functional assessment of cancer treatment-lung; Compare the effects of different nutritional risks on body mass index(BMI), hematological indexes(total protein, albumin, hemoglobin) and quality of life; analyze the relationship between malnutrition risk and quality of life, and explore the factors affecting quality of life. Results: Among the 518 patients with advanced lung cancer, 307(59.3%) were at risk of malnutrition. Compared with patients without malnutrition risk, patients with malnutrition risk had lower levels of nutrition-related indicators,such as BMI,total protein, albumin and hemoglobin,all differences had statistically significance(P<0.05). FACT-L overall score of patients without malnutrition risk was 88.63±9.23 points, which was significantly higher than that of patients with malnutrition risk(82.74±9.91 points)(P<0.05). Correlation analysis showed that FACT-L overall score was positively correlated with BMI and albumin, and negatively correlated with NRS2002 score. Regression analysis showed that NRS 2002 score was a risk factor for FACT-L overall score(P<0.05). Couclusion: The proportion of patients with advanced lung cancer at risk of malnutrition is high, and their nutrition-related indicators are significantly lower than those without malnutrition risk. The higher levels of nutrition-related indicators and the lower level of NRS 2002 score, the higher quality of life in patients; with malnutrition risk is a risk factor for quality of life.Nutrition supporting and active intervention measures should be taken for patients with malnutrition risk in clinical practice.

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