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右美托咪定对脓毒症时巨噬细胞极化干预的研究进展
作者:王滔1  潘瑞1  温建立2  马兴龙2 
单位:1. 遵义医科大学第三附属医院/遵义市第一人民医院 急诊医学, 贵州 遵义 563000;
2. 遵义医科大学第三附属医院/遵义市第一人民医院 重症医学科, 贵州 遵义 563000
关键词:右美托咪定 脓毒症 巨噬细胞 极化 信号通路 药理作用 研究进展 综述 
分类号:R614;R459.7
出版年·卷·期(页码):2022·50·第九期(1213-1218)
摘要:

脓毒症定义为感染引起宿主反应失调,导致危及生命的器官功能障碍。巨噬细胞作为脓毒症时参与免疫应答的重要细胞之一,受多种信号通路诱导分化(即M1/M2型)来改善炎症反应。近年来,右美托咪定(DEX)被发现与脓毒症免疫方面有着密切关系。因此,本文作者从DEX对脓毒症巨噬细胞的干预机制现状出发,对DEX干预诱导巨噬细胞极化相关信号通路的研究进展作一综述,以为临床提供治疗靶点。

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