Objective: Through the analysis of the important abnormal results of the physical examination in Luzhou area,the guiding significance,management,clinical disease prevention was discussed.Methods: A total of 78 280 healthy people from our health management center from May 2020 to May 2021 were selected as the research objects,including six categories:laboratory,ultrasonic,radiographic,endoscopy,electrocardiogram,cervical thinprep cytologic test.Grouping by gender and age was performed to compare the distribution and differences of important abnormal results in different gender and age groups.Results: Among the 78 280 healthy people,5 176 cases of important abnormal results were found,and the detection rate of important abnormal results was 7%(5 176/78 280),aged 23-95 years,with an average age of (50.3±11.2) years,and the proportion of males 53.9%(2 788/5 176),the detection rate was about 7.3%(2 788/38 299),the proportion of women was 46.1%(2 388/5 176),the detection rate was about 6%(2 388/39 981),the difference was statistically significant (χ²=54.091,P<0.001).The detection rate of males was higher than that of females in different age groups,and it increased with age,the difference being statistically significant (χ²=59.681,P<0.001).The proportion of important abnormal results of physical examinations under the age of 40 was 19.7%(1 018/5 176),the detection rate was 2.52%(1 018/40 410),and the proportion of important abnormal results of physical examinations over 40 years old was 80.3%(4 158/5 176),the detection rate was 10.98%(4 158/37 870).Important abnormal results are mostly image examinations,laboratory examinations,and ultrasonography.The detection rates of important abnormal results in male and female physical examinations were higher for pulmonary nodules and masses,pulmonary tuberculosis and thyroid nodules,and the detection rates of pulmonary nodules,masses and pulmonary tuberculosis were higher in males than in females,with statistical significance (χ²=12.946,P<0.001;χ²=27.931,P<0.001),the detection rate of thyroid nodules in females was higher than that in males,with a statistical significance (χ²=61.807,P<0.001).The detection rates of high triglyceride,high blood sugar and high tumor markers in male and female physical examinations were also higher,and the detection rate in males was higher than that in females,with a statistical significance (χ²=127.336,P<0.001;χ²=34.982,P<0.001;χ²=29.868,P<0.001).Male and female arrhythmias were dominated by frequent premature ventricular contractions,pathological Q waves and ST-T changes,and the detection rate in males was higher than that in females (χ²=12.482, P<0.001;χ²=23.8,P<0.001).There was a significant age group difference between males and females with suspicious gastrointestinal malignant lesions (χ²=12.055, P=0.007).In addition,the detection rate of carotid artery stenosis was higher in males over 60 years old (39 cases,0.6%).The problems of breast nodules (179 cases,0.4%),uterus and appendages (85 cases,0.2%),and cervical precancerous lesions (80 cases,0.7%) in female physical examinations were also more prominent in population under the age of 60.Conclusions:People older than 40 should pay attention to the comprehensive and personalized physical examination plans,with special emphasis on screening for hyperglycemia,hyperlipidemia,tumor markers,lung,thyroid,urinary system,digestive system,and cardiovascular system.Women under the age of 60 should pay attention to the screening of breast,uterus and appendages,and cervical thinprep cytologic test,in order to achieve effective screening and management,early clinical diagnosis and treatment.