鼻咽癌患者miR-214-3p表达意义及与预后的关系分析-现代医学

鼻咽癌患者miR-214-3p表达意义及与预后的关系分析

单位：1. 武汉科技大学附属汉阳医院耳鼻喉科, 湖北武汉 430000;
2. 黄石市第四医院耳鼻喉科, 湖北黄石 435000

分类号：R739.6

出版年·卷·期（页码）：2022·50·第八期（974-979）

摘要：

目的：探讨鼻咽癌患者微小核糖核酸-214-3p(miR-214-3p)表达情况，分析其与预后的关系。方法：选取汉阳医院2015年7月—2018年7月收治的148例鼻咽癌患者为研究对象，将其作为鼻咽癌组，取同期收治的良性鼻咽肿物患者43例为对照组。两组均通过手术获取样本组织检测miR-214-3p相对表达水平，利用受试者工作特征曲线(ROC)分析miR-214-3p表达诊断鼻咽癌的曲线下面积(AUC)。术后随访3年，采用COX多因素模型分析鼻咽癌预后危险因素，观察miR-214-3p表达与患者生存情况的关系。结果：鼻咽癌组miR-214-3p相对表达量高于对照组，miR-214-3p表达诊断鼻咽癌的AUC为0.792(P＜0.05)。COX多元回归性模型分析显示淋巴结转移、临床分期Ⅲ期、低分化、颅神经损伤、miR-214-3p高表达是鼻咽癌预后不良危险因素，术后放/化疗则为预后保护因素(P＜0.05)。miR-214-3p高表达组无瘤与总生存期短于低表达组，无瘤与累积生存率低于低表达组(P＜0.05)。结论：鼻咽癌组织中miR-214-3p表达增高，其表达上调与鼻咽癌预后不良有关，对预后评估有重要意义。

Objective: To investigate the expression of microrna-214-3p (miR-214-3p) in patients with nasopharyngeal carcinoma and analyze its relationship with prognosis.Methods: 148 patients with nasopharyngeal carcinoma treated in Hanyang hospital from July 2015 to July 2018 were selected as the research objects,who were taken as nasopharyngeal carcinoma group,while 43 patients with benign nasopharyngeal masses treated in the same period were taken as control group.The relative expression level of miR-214-3p was detected in the sample tissues obtained in surgery in both groups.The area under the curve (AUC) of miR-214-3p expression in the diagnosis of nasopharyngeal carcinoma was analyzed by receiver operating characteristic curve (ROC).The patients were followed up for 3 years.Cox multivariate model was used to analyze the prognostic risk factors of nasopharyngeal carcinoma,and the relationship between the expression of miR-214-3p and the survival of patients was observed.Results: The relative expression of miR-214-3p in nasopharyngeal carcinoma group was higher than that in the control group.The AUC of miR-214-3p expression in the diagnosis of nasopharyngeal carcinoma was 0.792(P<0.05).Cox multiple regression model analysis showed that lymph node metastasis,clinical stage Ⅲ,low differentiation,cranial nerve injury and high expression of miR-214-3p were the risk factors of poor prognosis of nasopharyngeal carcinoma,and postoperative radiotherapy/chemotherapy were the protective factors of prognosis (P<0.05).The tumor free and overall survival time of miR-214-3p high expression group was shorter than those of the low expression group,and the tumor free and cumulative survival rate was lower than that of the low expression group (P<0.05).Conclusion: The expression of miR-214-3p is increased in nasopharyngeal carcinoma,which is related to the poor prognosis of nasopharyngeal carcinoma.

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