网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
儿茶酚抑素与代谢相关性疾病
作者:黄萍  曹明明 
单位:哈尔滨医科大学附属第一医院 内分泌科, 黑龙江 哈尔滨 150000
关键词:儿茶酚抑素 代谢相关性疾病 肥胖 糖尿病 综述 
分类号:R589
出版年·卷·期(页码):2022·50·第七期(909-913)
摘要:

蛋白质、脂肪和碳水化合物等物质出现代谢紊乱时可促进代谢相关疾病的发生发展。儿茶酚抑素(CST)作为一种颗粒糖蛋白家族,包括嗜铬粒蛋白(Cg)A、CgB等及其水解产物,在调节代谢相关性疾病中发挥重要作用。本文作者就两者的研究进展作一综述。

参考文献:

[1] HEROLD Z, DOLESCHALL M, SOMOGYI A.Role and function of granin proteins in diabetes mellitus[J].World J Diabetes, 2021, 12(7):1081-1092.
[2] TROGER J, THEURL M, KIRCHMAIR R, et al.Granin-derived peptides[J].Prog Neurobiol, 2017, 154:37-61.
[3] MAHATA S K, MAHATA M, FUNG M M, et al.Catestatin:a multifunctional peptide from chromogranin A[J].Regul Pept, 2010, 162(1-3):33-43.
[4] MAHATA S K, O'CONNOR D T, MAHATA M, et al.Novel autocrine feedback control of catecholamine release.A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist[J].J Clin Invest, 1997, 100(6):1623-1633.
[5] BANDYOPADHYAY G K, VU C U, GENTILE S, et al.Catestatin(chromogranin A(352-372)) and novel effects on mobilization of fat from adipose tissue through regulation of adrenergic and leptin signaling[J].J Biol Chem, 2012, 287(27):23141-23151.
[6] MELE M, IACHETTA G, ALO R, et al.Catestatin and GABA(A)R related feeding habits rely on dopamine, ghrelin plus leptin neuroreceptor expression variations[J].Physiol Behav, 2016, 157:225-230.
[7] YING W, MAHATA S, BANDYOPADHYAY G K, et al.Catestatin inhibits obesity-induced macrophage infiltration and inflammation in the liver and suppresses hepatic glucose production, leading to improved insulin sensitivity[J].Diabetes, 2018, 67(5):841-848.
[8] DURAKOGLUGIL M E, AYAZ T, KOCAMAN S A, et al.The relationship of plasma catestatin concentrations with metabolic and vascular parameters in untreated hypertensive patients:influence on high-density lipoprotein cholesterol[J].Anatol J Cardiol, 2015, 15(7):577-585.
[9] BOROVAC J A, DOGAS Z, SUPE-DOMIC D, et al.Catestatin serum levels are increased in male patients with obstructive sleep apnea[J].Sleep Breath, 2019, 23(2):473-481.
[10] OZCAN U, CAO Q, YILMAZ E, et al.Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes[J].Science, 2004, 306(5695):457-461.
[11] DASGUPTA A, BANDYOPADHYAY G K, RAY I, et al.Catestatin improves insulin sensitivity by attenuating endoplasmic reticulum stress:in vivo and in silico validation[J].Comput Struct Biotechnol J, 2020, 18:464-481.
[12] RABBI M F, MUNYAKA P M, EISSA N, et al.Human catestatin alters gut microbiota composition in mice[J].Front Microbiol, 2016, 7:2151.
[13] RABBI M F, LABIS B, METZ-BOUTIGUE M H, et al.Catestatin decreases macrophage function in two mouse models of experimental colitis[J].Biochem Pharmacol, 2014, 89(3):386-398.
[14] MAHATA S K, YING W, MUNTJEWERFF E M, et al.Catestatin improves insulin sensitivity by promoting M1-M2 polarization and inhibiting obesity-induced macrophage infiltration and gluconeogenesis in liver[J].FASEB J, 2019, 33(S1):813-834.
[15] RABBI M F, EISSA N, MUNYAKA P M, et al.Reactivation of intestinal inflammation is suppressed by catestatin in a murine model of colitis via M1 macrophages and not the gut microbiota[J].Front Immunol, 2017, 8:985.
[16] EISSA N, HUSSEIN H, MESGNA R, et al.Catestatin regulates epithelial cell dynamics to improve intestinal inflammation[J].Vaccines(Basel), 2018, 6(4):67.
[17] GAEDE A H, PILOWSKY P M.Catestatin, a chromogranin A-derived peptide, is sympathoinhibitory and attenuates sympathetic barosensitivity and the chemoreflex in rat CVLM[J].Am J Physiol Regul Integr Comp Physiol, 2012, 302(3):R365-R372.
[18] BRIOLAT J, WU S D, MAHATA S K, et al.New antimicrobial activity for the catecholamine release-inhibitory peptide from chromogranin A[J].Cell Mol Life Sci, 2005, 62(3):377-385.
[19] KRUGER P G, MAHATA S K, HELLE K B.Catestatin(CgA344-364) stimulates rat mast cell release of histamine in a manner comparable to mastoparan and other cationic charged neuropeptides[J].Regul Pept, 2003, 114(1):29-35.
[20] KIRANMAYI M, CHIRASANI V R, ALLU P K, et al.Catestatin Gly364Ser variant alters systemic blood pressure and the risk for hypertension in human populations via endothelial nitric oxide pathway[J].Hypertension, 2016, 68(2):334-347.
[21] GAEDE A H, PILOWSKY P M.Catestatin in rat RVLM is sympathoexcitatory, increases barosensitivity, and attenuates chemosensitivity and the somatosympathetic reflex[J].Am J Physiol Regul Integr Comp Physiol, 2010, 299(6):R1538-R1545.
[22] O'CONNOR D T, ZHU G, RAO F, et al.Heritability and genome-wide linkage in US and australian twins identify novel genomic regions controlling chromogranin a:implications for secretion and blood pressure[J].Circulation, 2008, 118(3):247-257.
[23] MAHAPATRA N R, O'CONNOR D T, VAINGANKAR S M, et al.Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog[J].J Clin Invest, 2005, 115(7):1942-1952.
[24] CHEN H, LIU D, GE L, et al.Catestatin prevents endothelial inflammation and promotes thrombus resolution in acute pulmonary embolism in mice[J].Biosci Rep, 2019, 39(11):BSR20192236.
[25] XU W, YU H, LI W, et al.Plasma catestatin:a useful biomarker for coronary collateral development with chronic myocardial ischemia[J].PLoS One, 2016, 11(6):e149062.
[26] GALLO M P, FEMMINO S, ANTONIOTTI S, et al.Catestatin induces glucose uptake and GLUT4 trafficking in adult rat cardiomyocytes[J].Biomed Res Int, 2018, 2018:2086109.
[27] CHU S Y, PENG F, WANG J, et al.Catestatin in defense of oxidative-stress-induced apoptosis:a novel mechanism by activating the beta2 adrenergic receptor and PKB/Akt pathway in ischemic-reperfused myocardium[J].Peptides, 2020, 123:170200.
[28] ZHU D, XIE H, WANG X, et al.Catestatin-A novel predictor of left ventricular remodeling after acute myocardial infarction[J].Sci Rep, 2017, 7:44168.
[29] BOROVAC J A, GLAVAS D, SUSILOVIC G Z, et al.Catestatin in acutely decompensated heart failure patients:insights from the CATSTAT-HF study[J].J Clin Med, 2019, 8(8):1132.
[30] DU E, WANG A, FAN R, et al.Catestatin enhances ATP-induced activation of glial cells mediated by purinergic receptor P2X4[J].J Recept Signal Transduct Res, 2021, 42(2):160-168.
[31] DENG Z, LI C, LIU C, et al.Catestatin is involved in neuropathic pain mediated by purinergic receptor P2X4 in the spinal microglia of rats[J].Brain Res Bull, 2018, 142:138-146.
[32] MELE M, MORELLI S, FAZZARI G, et al.Application of the co-culture membrane system pointed to a protective role of catestatin on hippocampal plus hypothalamic neurons exposed to oxygen and glucose deprivation[J].Mol Neurobiol, 2017, 54(9):7369-7381.
[33] RADEK K A, LOPEZ-GARCIA B, HUPE M, et al.The neuroendocrine peptide catestatin is a cutaneous antimicrobial and induced in the skin after injury[J].J Invest Dermatol, 2008, 128(6):1525-1534.
[34] HOQ M I, NIYONSABA F, USHIO H, et al.Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes[J].J Dermatol Sci, 2011, 64(2):108-118.
[35] AUNG G, NIYONSABA F, USHIO H, et al.Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines[J].Immunology, 2011, 132(4):527-539.
[36] SIMUNOVIC M, SUPE-DOMIC D, KARIN Z, et al.Serum catestatin concentrations are decreased in obese children and adolescents[J].Pediatr Diabetes, 2019, 20(5):549-555.
[37] CANI P D, BIBILONI R, KNAUF C, et al.Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice[J].Diabetes, 2008, 57(6):1470-1481.
[38] MENG L, YE X J, DING W H, et al.Plasma catecholamine release-inhibitory peptide catestatin in patients with essential hypertension[J].J Cardiovasc Med(Hagerstown), 2011, 12(9):643-647.
[39] MAHATA S K, MAHATA M, PARMER R J, et al.Desensitization of catecholamine release.The novel catecholamine release-inhibitory peptide catestatin(chromogranin a344-364) acts at the receptor to prevent nicotinic cholinergic tolerance[J].J Biol Chem, 1999, 274(5):2920-2928.
[40] SCHILLACI G, DE VUONO S, PUCCI G.An endogenous brake on the sympathetic nervous system:the emerging role of catestatin in hypertension[J].J Cardiovasc Med(Hagerstown), 2011, 12(9):609-612.
[41] KOJIMA M, OZAWA N, MORI Y, et al.Catestatin prevents macrophage-driven atherosclerosis but not arterial injury-induced neointimal hyperplasia[J].Thromb Haemost, 2018, 118(1):182-194.
[42] CHEN Y, WANG X, YANG C, et al.Decreased circulating catestatin levels are associated with coronary artery disease:the emerging anti-inflammatory role[J].Atherosclerosis, 2019, 281:78-88.
[43] 樊小容, 谭小青, 张旭升, 等.儿茶酚抑素抑制血管钙化的作用及机制[J].海南医学, 2020, 31(5):545-548.

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 752231 位访问者


 ©《现代医学》编辑部
联系电话:025-83272481;83272479
电子邮件: xdyx@pub.seu.edu.cn

苏ICP备09058541