目的：探讨成人静息心率（RHR）与2型糖尿病（T2DM）发病风险的关系。方法：选取2013年6月至2014年6月“江苏省代谢综合征研究队列（2期）”中35岁以上符合条件的3 200名参与者。将基线RHR按照三分位数分为3组，即41～70次·min^-1组、71～76次·min^-1组和77～120次·min^-1组，收集研究对象的身高、体质量等指标数据，采用欧姆龙电子血压计进行RHR和血压测量，采集空腹静脉血检测空腹血糖（fasting plasma glucose，FPG）以及血脂4项等指标。使用Cox比例风险模型分析RHR与T2DM发生风险的关系。结果：经过平均5.2年的随访，共发生153例T2DM患者，发病密度为10.59/1 000人年。在校正混杂因素后，与第1组相比，第2、3组T2DM的发生风险比HR（95%CI）分别为1.19（0.78～1.82）、1.41（0.97～2.06）。与RHR最低分位组相比，男性和饮酒者RHR高分位组与T2DM发病风险的HR（95%CI）分别为1.83（1.02～3.26）、2.79（1.28～6.07），且RHR与年龄、体质量指数在T2DM发病风险中有显著交互作用（交互P<0.05）。结论：在男性和饮酒者中RHR增快与T2DM发病风险显著关联。

[1] SAEEDI P, PETERSOHN I, SALPEA P, et al.Global and regional diabetesprevalence estimates for 2019 and projections for 2030 and 2045:results from the International Diabetes Federation Diabetes Atlas, 9^thedition[J].Diabetes Res Clin Pract, 2019, 157:107843.
[2] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2020年版)[J].中华内分泌代谢杂志, 2021, 37(4):311-398.
[3] 陈东, 董玲玲, 黄宏, 等.静息心率与射血分数降低性心力衰竭伴心房颤动患者预后的关联[J].中华高血压杂志, 2021, 29(10):986-990.
[4] BÖHM M, REIL J C, DEEDWANIA P, et al.Resting heart rate:risk indicator and emerging risk factor in cardiovascular disease[J]. Am J Med, 2015, 128(3):219-228.
[5] ZHANG X, SHU X O, XIANG Y B, et al.Resting heart rate and risk of type 2 diabetes in women[J].Int J Epidemiol, 2010, 39:900-906.
[6] WANG L, CUI L, WANG Y, et al.Resting heart rate and the risk of developing impaired fasting glucoseand diabetes:the Kailuan prospective study[J].Int J Epidemiol, 2015, 44:689-699.
[7] CARNETHON M R, GOLDEN S H, FOLSOM A R, et al.Prospective investigation of autonomic nervous systemfunction and the development of type 2 diabetes:the AtherosclerosisRisk In Communities study, 1987-1998[J].Circulation, 2003, 107:2190-2195.
[8] CARNETHON M R, YAN L, GREENLAND P, et al. Resting heart rate in middle age and diabetesdevelopment in older age[J].Diabetes Care, 2008, 31:335-339.
[9] 宗菁, 强德仁, 孔晓玲, 等.武进农村地区人群静息心率与2型糖尿病发病风险的队列研究[J].现代预防医学, 2021, 48(22):4104-4107.
[10] AUNE D, HARTAIGH B O, VATTEN L J.Resting heart rate and the risk of type 2 diabetes:a systematic review and dose response meta-analysis of cohort studies[J]. Nutr Metab Cardiovasc Dis, 2015, 25(6):526-534.
[11] 王盼盼, 李玉倩, 刘晓田, 等.静息心率与2型糖尿病发病风险的Meta分析[J].中华疾病控制杂志, 2017, 21(3):245-249.
[12] SATO K K, HAYASHI T, HARITA N, et al.Relationship between drinking patterns and the risk of type 2 diabetes:the Kansai Healthcare Study[J]. J Epidemiol Community Health, 2012, 66(6):507-511.
[13] XU C, ZHONG J, ZHU H, et al. Independent and interactive associations of heart rate and body mass index or blood pressure with type 2 diabetes mellitus incidence:a prospective cohort study[J].J Diabetes Investig, 2019, 10(4):1068-1074.
[14] HAMAOKA T, MURAI H, HIRAI T, et al. Different responses of muscle sympathetic nerve activity to dapagliflozin between patients with type 2 diabetes with and without heart failure[J].J Am Heart Assoc, 2021, 10(22):e022637.
[15] JORDAN J, TANK J, HEUSSER K, et al.The effect of empagliflozin on muscle sympathetic nerve activity in patients with type II diabetes mellitus[J].J Am Soc Hypertens, 2017, 11(9):604-612.
[16] JIANG L, SU H, WU X, et al.Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease[J].Nature Commun, 2020, 11(1):1517.
[17] LONG T, WANG J, HAN X, et al.Association between resting heart rate and incident diabetes risk:a Mendelian randomization study[J].Acta Diabetol, 2019, 56(9):1037-1044.
[18] STUCKEY M I, PETRELLA R J. Heart rate variability in type 2 diabetes mellitus[J].Crit Rev Biomed Eng, 2013, 41(2):137-147.
[19] FAULKNER M S, SMART M J.Sleep quality and heart rate variability in adolescents with type 1 or type 2 diabetes[J].J Diabetes Complications, 2021, 35(12):108049.