Objective: To explore the strategy and practice of improving the psychological status of postgraduates in clinical degree from the perspective of positive psychology. Methods: A self-designed questionnaire was used to investigate the mental health of 377 professional postgraduate students from 3 grades. The contents of the questionnaire include general situation, symptom checklist 90(SCL-90) and Eysenck Personality Questionnaire(adult EPQ) analysis to understand their mental health status. Results: 371 professional postgraduates participated in the baseline survey, including 143 males and 228 females.15.09% of the professional postgraduates had work experience and 51.75% of postgraduates were in the non-surgical departments. The average age was 24.70 years old. The positive rate of SCL-90 mental health screening was 23.45%. Introverted and unstable postgraduates had the highest detection rate of psychological problems. Conclusion: Using the theory of positive psychology to carry out the practice of mental health education courses and activities in the training process of clinical professional postgraduates will help to improve and adjust the mental state of postgraduates, promote their positive personality development and positive mentality, help them better adapt to clinical training, and indirectly improve the training quality.