Objective: To investigate the expression and clinical significance of serum stromal cell-derived factor-1(SDF-1) and CXC chemokine receptor 7(CXCR7) in patients with diabetic neovascular glaucoma(NVG). Methods: A total of 71 patients with NVG caused by diabetic retinopathy admitted in the Third Hospital of Wuhan from September 2018 to December 2020 were selected as the study group. According to the clinical manifestations of NVG patients, they were divided into stage Ⅰ(13 cases), stage Ⅱ(40 cases) and stage Ⅲ(18 cases). At the same time, 53 patients with age-related cataract treated in the Third Hospital of Wuhan were randomly included as the control group. The levels of serum SDF-1, CXCR7, vascular endothelial growth factor(VEGF) and interleukin-6(IL-6) were detected by enzyme linked immunosorbent assay. the levels of serum SDF-1, CXCR7, VEGF and IL-6 in each group were compared, the correlation between serum SDF-1 and CXCR7, and their correlation with VEGF, IL-6 in study group were analyzed, the predictive value of serum SDF-1, CXCR7, VEGF and IL-6 levels for NVG was analyzed by receiver operating characteristic (ROC)curve. Results: Compared with those in the control group, the levels of serum SDF-1, CXCR7, VEGF and IL-6 in the study group were significantly increased(P<0.05); the levels of serum SDF-1, CXCR7, VEGF and IL-6 increased significantly with the upgrade of clinical stage of NVG(P<0.05); Pearson results showed that the level of serum SDF-1 was positively correlated with CXCR7, VEGF and IL-6 levels in study group(r=0.496, 0.413, 0.437, all P<0.05), the level of serum CXCR7 was positively correlated with VEGF and IL-6 levels(r=0.429, 0.441, all P<0.05); the area under the curve(AUC) of serum SDF-1, CXCR7, VEGF and IL-6 in predicting NVG was 0.859(95%CI 0.785-0.915), 0.890(95%CI 0.823-0.937), 0.798(95%CI 0.716-0.865) and 0.849(95%CI 0.774-0.907), respectively. The AUC of serum SDF-1 and CXCR7 in predicting NVG was 0.946(95%CI 0.883-0.965), which was significantly different from that of single factor(P<0.05); the AUC of levels of serum SDF-1, CXCR7, VEGF and IL-6 in predicting NVG was 0.967(95%CI 0.916-0.986), which was significantly different from that of single factor diagnosis and SDF-1, CXCR7 combined diagnosis(P<0.05). Conclusion: The levels of serum SDF-1 and CXCR7 in patients with NVG increase with the aggravation of clinical grading, and are positively correlated with the levels of serum VEGF and IL-6. They have certain diagnostic value for the occurrence of NVG, and may be used as potential biological indicators to indicate the occurrence and development of NVG. |
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