目的:研究影响颅内动脉瘤大小的相关因素,为预测颅内动脉瘤大小及预防颅内动脉瘤破裂提供理论依据。方法:选取239例颅内动脉瘤患者,按照颅内动脉瘤直径大小分为3组,分别为小动脉瘤组、中动脉瘤组和大动脉瘤组。对239例患者的年龄、性别、基础疾病史、吸烟饮酒史、血液学检查指标、用药史等因素进行分析,计数资料分析采用Mantel-Haenszel卡方检验,多组间比较采用单因素方差分析,相关性分析采用Pearson相关性分析,通过Logistic回归分析进行多因素分析。结果:不同大小动脉瘤组间服用他汀类药物比例差异有统计学意义(χ²=9.307,P=0.01),服用他汀与动脉瘤大小存在线性关系,且呈正相关(r=0.191,P<0.05);不同大小动脉瘤组间性别、饮酒、高血压病、冠心病、脑卒中、服用阿司匹林、年龄、D-二聚体、同型半胱氨酸(Hcy)等方面比较差异均无统计学意义(P>0.05);不同大小动脉瘤组间吸烟史、糖尿病、高脂血症、服用氯吡格雷、脂蛋白相关磷脂酶A2比较可能有统计学意义,P值分别为0.068、0.057、0.067、0.060、0.068;在调整性别、年龄、吸烟、饮酒史、基础疾病史等因素后,不同大小动脉瘤组间服用他汀类药物比较仍然有统计学意义。结论:服用他汀类药物一定程度上能够减少动脉瘤的破裂,并且能够预测动脉瘤的大小。

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