[1] BEEKEN L J,TING D S J,SIDNEY L E.Potential of mesenchymal stem cells as topical immunomodulatory cell therapies for ocular surface inflammatory disorders[J].Stem Cells Transl Med,2021,10(1):39-49.
[2] CHEN Y,HU Y,YANG L，et al.Runx2 alleviates high glucose-suppressed osteogenic differentiation via PI3K/AKT/GSK3β/β-catenin pathway[J].Cell Biol Int,2017,41(8):822-832.
[3] ZHANG Y L,LIU L,PEYMANFAR Y,et al.Roles of microRNAs in osteogenesis or adipogenesis differentiation of bone marrow stromal progenitor cells[J].Int J Mol Sci,2021,22(13):52-55.
[4] LEE S Y,PARK K H,LEE G,et al.Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss[J].Exp Mol Med,2021,53(4):591-604.
[5] CHEN Q,SHOU P,ZHENG C,et al.Fate decision of mesenchymal stem cells:Adipocytes or osteoblasts?[J].Cell Death Differ,2016,23:1128-1139.
[6] LIU X,BAO C Y,XU H K,et al.Osteoprotegerin gene-modified BMSCs with hydroxyapatite scaffold for treating critical-sized mandibular defects in ovariectomized osteoporotic rats[J].Acta Biomater,2016,42(3):378-388.
[7] JI Q B,ZHENG Y X,ZHANG G Q,et al.Single-cell RNA-seq analysis reveals the progression of human osteoarthritis[J].Ann Rheum Dis,2019,78(1):100-110.
[8] MASSON-MEYERS D S,TAYEBI L.Vascularization strategies in tissue engineering approaches for soft tissue repair[J].J Tissue Eng Regen Med,2021,15(9):747-762.
[9] VANDERBECK A N,MAILLARD I.Notch in the niche:New insights into the role of notch signaling in the bone marrow[J].Haematologica,2019,104(11):2117-2119.
[10] ZHANG Y,SHI T W,HE Y H.GPR35 regulates osteogenesis via the Wnt/GSK3β/β-catenin signaling pathway[J].Biochem Biophys Res Commun,2021,556(1):171-178.
[11] 史东梅，董明，陆颖，等.PI3K/Akt信号通路与骨破坏：问题与机制[J].中国组织工程研究，2020，24(23)：3716-3722.
[12] SAMI A,KARSY M.Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma:Novel therapeutic agents and advances in understanding[J].Tumour Biol,2013,34(4):1991-2002.
[13] TANG L Y,WU M,LU S Y,et al.Fgf9 negatively regulates bone mass by inhibiting osteogenesis and promoting osteoclastogenesis via MAPK and PI3K/AKT signaling[J].J Bone Miner Res,2021,36:779-791.
[14] POLIVKA J Jr，JANKU F.Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway[J].Pharmacol Ther，2014,142(2):164-175.
[15] ZHAO F,XU Y,OY Y,et al.Silencing of miR-483-5p alleviates postmenopausal osteoporosis by targeting SATB2 and PI3K/AKT pathway[J].Aging(Albany NY),2021,13(5):6945-6956.
[16] FU H,JIN C H,ZHU Q X,et al.Dysregulated expressions of PTEN,NF-κB,WWP2,p53 and c-Myc in different subtypes of B cell lymphoma and reactive follicular hyperplasia[J].Am J Transl Res,2019,11(2):1092-1101.
[17] SANDOVA V,PAVLASOVA G M,SEDA V,et al.IL4-STAT6 signaling induces CD20 in chronic lymphocytic leukemia and this axis is repressed by PI3Kδ inhibitor idelalisib[J].Haematologica,2021,106(11):2995-2999.
[18] 钟佳琳，郑立，贺花，等.PI3K/Akt信号通路相关的生物学调控机制研究进展[J].基因组学与应用生物学，2019，38(1):143-147.
[19] HUANG X,HUANG D H,ZHU T,et al.Sustained zinc release in cooperation with CaP scaffold promoted bone regeneration via directing stem cell fate and triggering a pro-healing immune stimuli[J].J Nanobiotechnology,2021,19(1):207.
[20] XU J X,FU L F,BAI J W,et al.Low-dose IL-34 has no effect on osteoclastogenesis but promotes osteogenesis of hBMSCs partly via activation of the PI3K/AKT and ERK signaling pathways[J].Stem Cell Res Ther,2021,12:268.
[21] 何艳，布海切木·卡德尔，周晓珊，等.藏红花素通过调控PI3K/Akt信号通路抑制成骨细胞凋亡引起的骨质疏松[J].医学研究杂志，2021，50(1)：85-90.
[22] 熊艺璇.姜黄素通过PI3K/AKT/Nrf2信号通路促进牙周膜干细胞的成骨分化[D].济南：山东大学，2020.
[23] 林院，徐杰，罗奋棋，等.基于PI3K/AKT信号通路研究丹酚酸B对成骨细胞骨形成的调控作用[J].中国老年学杂志，2019，39(11)：2760-2763.
[24] 吴雨蒙，王莹，吴琪，等.二仙汤对过氧化氢诱导的成骨细胞蛋白组学及PI3K信号通路的影响[J].中国中药杂志，2021,46(15):9.
[25] LI M Y,CONG R,YANG L Y,et al.A novel lncRNA LNC_000052 leads to the dysfunction of osteoporotic BMSCs via the miR-96-5p-PIK3R1 axis[J].Cell Death Dis,2020,11(9):795.
[26] MENG Y B,LI X,LI Z Y,et al.microRNA-21 promotes osteogenic differentiation of mesenchymal stem cells by the PI3K/β-catenin pathway[J].Orthop Res,2015,33(7):957-964.
[27] XIA P,GU R,ZHANG W,et al.MicroRNA-200c promotes osteogenic differentiation of human bone mesenchymal stem cells through activating the AKT/β-Catenin signaling pathway via downregulating Myd88[J].Cell Physiol,2019,234(12),22675-22686.
[28] SHI L,FENG L,LIU Y,et al.MicroRNA-218 promotes osteogenic differentiation of mesenchymal stem cells and accelerates bone fracture healing[J].Calcified Tissue International,2018,103(3):1-10.
[29] TONG Y X,FENG W,WU Y M,et al.Mechano-growth factor accelerates the proliferation and osteogenic differentiation of rabbit mesenchymal stem cells through the PI3K/AKT pathway[J].BMC Biochem,2015,16:1.
[30] 黎鑫.IGF-1通过PI3K/Akt信号通路对BMSCs增殖和凋亡的影响[D].重庆：重庆医科大学，2018.
[31] LI M W,SUN X F,MA L,et al.SDF-1/CXCR4 axis induces human dental pulp stem cell migration through FAK/PI3K/Akt and GSK3β/β-catenin pathways[J].Sci Rep,2017,7(2):40161.
[32] 李洋，陈前昭，邵英，等.骨形态蛋白9诱导干细胞骨向分化与环氧酶-2及PI3K/Akt的关系研究[J].中国药理学通报，2017，33(7)：908-915.
[33] THOMAS S,JAGANATHAN B G.Signaling network regulating osteogenesis in mesenchymal stem cells[J].J Cell Commun Signal,2022,16(1):47-61.
[34] WANG Y Y,YANG K,WEN X J.p75NTR mice exhibit an alveolar bone loss phenotype and inhibited PI3K/Akt/β-catenin pathway[J].Cell Prolif,2020,53(4):e12800.
[35] BURGERS T A,HOFFMANN M F,COLLINS C J,et al.Mice lacking pten in osteoblasts have improved intramembranous and late endochondral fracture healing[J].PLoS One,2013,8(5):e63857. |
