血清hs-CRP水平与青少年首发抑郁症的相关性研究-现代医学

血清hs-CRP水平与青少年首发抑郁症的相关性研究

单位：1. 徐州医科大学附属徐州东方医院儿少精神科, 江苏徐州 221004;
2. 徐州医科大学公共卫生学院, 江苏徐州 221004

分类号：R749.4

出版年·卷·期（页码）：2022·50·第一期（105-110）

摘要：

目的：探讨青少年首发抑郁症患者在治疗前后其血清超敏C反应蛋白(hs-CRP)水平的变化及其与病情严重程度的相关性。方法：纳入60例青少年首发抑郁症患者(病例组)、60例健康青少年(对照组)，病例组应用盐酸舍曲林治疗6周，测量病例组基线及治疗后1、2、4、6周末和对照组入组时的血清hs-CRP水平，应用汉密尔顿抑郁量表(HAMD-24)评定被试的抑郁症状严重程度。结果：病例组在治疗前及治疗后第1、2、4、6周末的HAMD-24评分总分和血清hs-CRP水平均显著高于对照组(P＜0.01)。相关分析显示，病例组患者在治疗前及治疗后第1、2、4、6周末的血清hs-CRP水平与HAMD-24评分呈正相关(P＜0.01)。结论：青少年首发抑郁症患者的血清hs-CRP水平显著高于对照组，血清hs-CRP水平能够反映青少年首发抑郁症患者的病情严重程度。

Objective:To investigate the changes of hypersensitive C-reactive protein (hs-CRP) level of adolescents with first-episode depression before and after treatment and its correlation with the severity of the disease. Methods: 60 adolescents with first-episode depression were included as case group who weregiven sertraline hydrochloride for 6 weeks of clinical treatment, and 60 healthy adolescents of the same age were selected as control group. Serum hs-CRP levels were measured at baseline and at the end of 1, 2, 4 and 6 weeks after treatment, and at the time of enrollment in the control group. The Hamilton Depression Scale(HAMD-24) was used to assess the mood and the severity and condition changes of the two groups. Results: The total scores of the HAMD-24 and the serum hs-CRP levels of the case group measured before treatment and the first, second, fourth, and sixth week after treatment were significantly higher than those of the healthy control group(P＜0.01). Correlation analysis showed that the serum hs-CRP levels of the adolescents with first-episode depression before treatment and the first, second, fourth, and sixth weekend after treatment were positively correlated with the total score of HAMD-24(P＜0.01).There was a positive correlation between the level of serum hs-CRP in the case group before treatment and total score of HAMD-24. Conclusion: Serum hs-CRP levels are significantly higher in adolescent first-episode depression patients compared with the control group, and serum hs-CRP levels could reflect the severity of the condition in adolescent first-episode depression patients.

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