目的： 研究膳食纤维Fibersol^®-2对人体餐后血糖、胰岛素水平和胰岛素敏感性的影响。方法： 研究招募30~39岁的健康成年人为受试者，采用随机对照交叉试验设计，根据进食米饭种类不同随机分为混合米饭组（添加Fibersol^®-2）和普通米饭组，间隔1周后进行第2次的交叉试验。每次试验分别采集空腹（2次，间隔5 min）、餐后15、30、45、60、90、120 min 7个时间点的血液，分离血清，测定各时间点的血糖和胰岛素水平，分别计算曲线下面积，用胰岛素与血糖应答曲线下面积比（Ins/Glu）评估机体对胰岛素的敏感性。结果： 在餐后45、60、90、120 min时，混合米饭组的血糖水平均显著低于同时点普通米饭组（P<0.05）；在餐后45、60、120 min时，混合米饭组的血清胰岛素水平均显著低于普通米饭组（P<0.05）。同时，混合米饭组餐后2 h血糖和胰岛素曲线下面积均显著低于普通米饭组（P<0.05）。混合米饭组Ins/Glu值在餐后30、45、60 min 3个时间点均显著高于普通米饭组（P<0.05）。结论： 添加膳食纤维Fibersol^®-2具有降低餐后血糖和胰岛素水平、提高胰岛素敏感性的作用。

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